Anti-CXXC1 Antibody (CAB13423)
- SKU:
- CAB13423
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-CXXC1 Antibody |
| 抗体コード: | CAB13423 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF IP |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human CXXC1 (NP_001095124.1). |
| 申し込み: | WB IF IP |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 IP 1:20 - 1:50 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HepG2, BT-474, HepG2, Mouse thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human CXXC1 (NP_001095124.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEGD GSDP EPPD AGED SKSE NGEN APIY CICR KPDI NCFM IGCD NCNE WFHG DCIR ITEK MAKA IREW YCRE CREK DPKL EIRY RHKK SRER DGNE RDSS EPRD EGGG RKRP VPDP DLQR RAGS GTGV GAML ARGS ASPH KSSP QPLV ATPS QHHQ QQQQ QIKR SARM CGEC EACR RTED CGHC DFCR DMKK FGGP NKIR QKCR LRQC QL |
| 遺伝子ID: | 30827 |
| Uniprot: | Q9P0U4 |
| セルラーロケーション: | Nucleus speckle |
| 計算された分子量: | 75kDa/76kDa |
| 観察された分子量: | 80kDa |
| 同義語: | CXXC1, 2410002I16Rik, 5830420C16Rik, CFP1, CGBP, HsT2645, PCCX1, PHF18, SPP1, ZCGPC1, hCGBP |
| バックグラウンド: | This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. |
| UniProt Protein Function: | CXXC1: Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor Chromosomal Location of Human Ortholog: 18q12 Cellular Component: cytoplasm; histone methyltransferase complex; nuclear speck; nucleoplasm; nucleus Molecular Function:histone lysine N-methyltransferase activity (H3-K4 specific); protein binding; unmethylated CpG binding Biological Process: histone H3-K4 methylation; positive regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a protein that functions as a transcriptional activator that binds specifically to non-methylated CpG motifs through its CXXC domain. The protein is a component of the SETD1 complex, regulates gene expression and is essential for vertebrate development. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q9P0U4 |
| NCBI GenInfo Identifier: | 20138037 |
| NCBI Gene ID: | 30827 |
| NCBI Accession: | Q9P0U4.2 |
| UniProt Secondary Accession: | Q9P0U4,Q8N2W4, Q96BC8, Q9P2V7, B2RC03, |
| UniProt Related Accession: | Q9P0U4 |
| Molecular Weight: | 76,227 Da |
| NCBI Full Name: | CXXC-type zinc finger protein 1 |
| NCBI Synonym Full Names: | CXXC finger protein 1 |
| NCBI Official Symbol: | CXXC1 |
| NCBI Official Synonym Symbols: | CFP1; CGBP; SPP1; PCCX1; PHF18; hCGBP; ZCGPC1; HsT2645; 2410002I16Rik; 5830420C16Rik |
| NCBI Protein Information: | CXXC-type zinc finger protein 1 |
| UniProt Protein Name: | CXXC-type zinc finger protein 1 |
| UniProt Synonym Protein Names: | CpG-binding protein; PHD finger and CXXC domain-containing protein 1 |
| Protein Family: | CXXC-type zinc finger protein |
| UniProt Gene Name: | CXXC1 |
| UniProt Entry Name: | CXXC1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CXXC1 antibody (CAB13423) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
 | Immunofluorescence analysis of A-549 cells using CXXC1 antibody (CAB13423). |
 | Immunoprecipitation analysis of 200ug extracts of HepG2 cells using 3ug CXXC1 antibody (CAB13423). Western blot was performed from the immunoprecipitate using CXXC1 antibody (CAB13423) at a dilition of 1:500. |
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