Anti-CXCR5 Antibody (CAB5268)
- SKU:
- CAB5268
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-CXCR5 Antibody |
| 抗体コード: | CAB5268 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CXCR5 (NP_001707.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | B cells, BT-474, Raji, Mouse liver |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human CXCR5 (NP_001707.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LPVA ITMC EFLG LAHC CLNP MLYT FAGV KFRS DLSR LLTK LGCT GPAS LCQL FPSW RRSS LSES ENAT SLTT F |
| 遺伝子ID: | 643 |
| Uniprot: | P32302 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 36kDa/41kDa |
| 観察された分子量: | 45kDa |
| 同義語: | CXCR5, BLR1, CD185, MDR15 |
| バックグラウンド: | This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | CXCR5: Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane Molecular Function:G-protein coupled receptor activity; protein binding; C-X-C chemokine receptor activity Biological Process: positive regulation of cytokinesis; G-protein coupled receptor protein signaling pathway; B cell activation; immune response; cell motility; chemotaxis; lymph node development |
| NCBI Summary: | This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P32302 |
| NCBI GenInfo Identifier: | 416718 |
| NCBI Gene ID: | 643 |
| NCBI Accession: | P32302.1 |
| UniProt Related Accession: | P32302 |
| Molecular Weight: | |
| NCBI Full Name: | C-X-C chemokine receptor type 5 |
| NCBI Synonym Full Names: | C-X-C motif chemokine receptor 5 |
| NCBI Official Symbol: | CXCR5 |
| NCBI Official Synonym Symbols: | BLR1; CD185; MDR15 |
| NCBI Protein Information: | C-X-C chemokine receptor type 5 |
| UniProt Protein Name: | C-X-C chemokine receptor type 5 |
| UniProt Synonym Protein Names: | Burkitt lymphoma receptor 1; Monocyte-derived receptor 15; MDR-15; CD_antigen: CD185 |
| UniProt Gene Name: | CXCR5 |
| UniProt Entry Name: | CXCR5_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CXCR5 antibody (CAB5268) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunofluorescence analysis of U2OS cells using CXCR5 antibody (CAB5268) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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