Anti-CUX1 Antibody (CAB2213)
- SKU:
- CAB2213
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CUX1 Antibody |
| 抗体コード: | CAB2213 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CUX1 (NP_001189472.1). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, Jurkat, MCF7, mouse brain, mouse testis, mouse kidney, rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human CUX1 (NP_001189472.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAAN VGSM FQYW KRFD LQQL QREL DATA TVLA NRQD ESEQ SRKR LIEQ SREF KKNT PEDL RKQV APLL KSFQ GEID ALSK RSKE AEAA FLNV YKRL IDVP DPVP ALDL GQQL QLKV QRLH DIET ENQK LRET LEEY NKEF AEVK NQEV TIKA LKEK IREY EQTL KNQA ETIA LEKE QKLQ NDFA EKER KLQE TQMS TTSK LEEA EHKV QSLQ TALE KTRT ELFD LKTK YDEE TTAK ADEI EMIM TDLE RANQ RAEV AQRE AETL REQL SSAN HSLQ LASQ |
| 遺伝子ID: | 1523 |
| Uniprot: | P39880/Q13948 |
| セルラーロケーション: | Golgi apparatus membrane, Single-pass type IV membrane protein |
| 計算された分子量: | 72-77kDa/147-165kDa |
| 観察された分子量: | 90kDa/110kDa/250kDa |
| 同義語: | CUX1, CASP, CDP, CDP/Cut, CDP1, COY1, CUTL1, CUX, Clox, Cux/CDP, GOLIM6, Nbla10317, p100, p110, p200, p75 |
| バックグラウンド: | The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified. |
| UniProt Protein Function: | CUTL1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA-binding; Membrane protein, integral; Transcription factor Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: integral to Golgi membrane; nucleus; cytosol Molecular Function:sequence-specific DNA binding; chromatin binding Biological Process: regulation of transcription from RNA polymerase II promoter; intra-Golgi vesicle-mediated transport; transcription, DNA-dependent; multicellular organismal development; auditory receptor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; kidney development; lung development |
| NCBI Summary: | The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011] |
| UniProt Code: | P39880 |
| NCBI GenInfo Identifier: | 296439379 |
| NCBI Gene ID: | 1523 |
| NCBI Accession: | P39880.3 |
| UniProt Secondary Accession: | P39880,Q6NYH4, Q75LE5, Q75MT2, Q75MT3, Q86UJ7, Q9UEV5 B3KV79, J3KQV9, |
| UniProt Related Accession: | P39880,Q13948 |
| Molecular Weight: | 77 kDa |
| NCBI Full Name: | Homeobox protein cut-like 1 |
| NCBI Synonym Full Names: | cut-like homeobox 1 |
| NCBI Official Symbol: | CUX1 |
| NCBI Official Synonym Symbols: | CDP; CUX; p75; CASP; CDP1; COY1; Clox; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317 |
| NCBI Protein Information: | protein CASP; cut homolog; homeobox protein cux-1; CCAAT displacement protein; golgi integral membrane protein 6; putative protein product of Nbla10317 |
| UniProt Protein Name: | Homeobox protein cut-like 1 |
| UniProt Synonym Protein Names: | CCAAT displacement protein; CDP; Homeobox protein cux-1 |
| Protein Family: | Homeobox protein |
| UniProt Gene Name: | CUX1 |
| UniProt Entry Name: | CUX1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CUX1 antibody (CAB2213) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of C6 cells using CUX1 antibody (CAB2213) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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