Anti-CTU2 Antibody (CAB13003)
- SKU:
- CAB13003
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-CTU2 Antibody |
| 抗体コード: | CAB13003 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 186-515 of human CTU2 (NP_001012777.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | A-431, Jurkat |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 186-515 of human CTU2 (NP_001012777.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | HVLG AGGG PGPT QGEE QPPQ PPLD PQNL ARPP APAQ TEAL SQLF CSVR TLTA KEEL LQTL RTHL ILHM ARAH GYSK VMTG DSCT RLAI KLMT NLAL GRGA FLAW DTGF SDER HGDV VVVR PMRD HTLK EVAF YNRL FSVP SVFT PAVD TKAP EKAS IHRL MEAF ILRL QTQF PSTV STVY RTSE KLVK GPRD GPAA GDSG PRCL LCMC ALDV DAAD SATA FGAQ TSSR LSQM QSPI PLTE TRTP PGPC CSPG VGWA QRCG QGAC RRED PQAC IEEQ LCYS CRVN MKDL PSLD PLPP YILA EAQL RTQR AWGL QEIR DCLI EDSD DEAG QS |
| 遺伝子ID: | 348180 |
| Uniprot: | Q2VPK5 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 46kDa/52kDa/56kDa |
| 観察された分子量: | 56kDa |
| 同義語: | CTU2, C16orf84, NCS2, UPF0432 |
| バックグラウンド: | This gene encodes a protein which is involved in the post-transcriptional modification of transfer RNAs (tRNAs). The encoded protein plays a role in thiolation of uridine residue present at the wobble position in a subset of tRNAs, resulting in enhanced codon reading accuracy. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | CTU2: Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Belongs to the CTU2/NCS2 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:RNA-binding Chromosomal Location of Human Ortholog: 16q24.3 Cellular Component: protein complex; mitochondrion; cytoplasm Molecular Function:protein binding; tRNA binding; nucleotidyltransferase activity Biological Process: protein urmylation; tRNA wobble uridine modification |
| UniProt Code: | Q2VPK5 |
| NCBI GenInfo Identifier: | 121941955 |
| NCBI Gene ID: | 348180 |
| NCBI Accession: | Q2VPK5.1 |
| UniProt Secondary Accession: | Q2VPK5,Q0P511, Q66K78, Q6P4C8, Q86SV4, B2RXK0, |
| UniProt Related Accession: | Q2VPK5 |
| Molecular Weight: | 52,467 Da |
| NCBI Full Name: | Cytoplasmic tRNA 2-thiolation protein 2 |
| NCBI Synonym Full Names: | cytosolic thiouridylase subunit 2 homolog (S. pombe) |
| NCBI Official Symbol: | CTU2 |
| NCBI Official Synonym Symbols: | NCS2; UPF0432; C16orf84 |
| NCBI Protein Information: | cytoplasmic tRNA 2-thiolation protein 2 |
| UniProt Protein Name: | Cytoplasmic tRNA 2-thiolation protein 2 |
| UniProt Gene Name: | CTU2 |
| UniProt Entry Name: | CTU2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CTU2 antibody (CAB13003) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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