Anti-CTSS Antibody (CAB1874)
- SKU:
- CAB1874
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-CTSS Antibody |
| 抗体コード: | CAB1874 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-331 of human CTSS (NP_004070.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 115-331 of human CTSS (NP_004070.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LPDS VDWR EKGC VTEV KYQG SCGA CWAF SAVG ALEA QLKL KTGK LVSL SAQN LVDC STEK YGNK GCNG GFMT TAFQ YIID NKGI DSDA SYPY KAMD QKCQ YDSK YRAA TCSK YTEL PYGR EDVL KEAV ANKG PVSV GVDA RHPS FFLY RSGV YYEP SCTQ NVNH GVLV VGYG DLNG KEYW LVKN SWGH NFGE EGYI RMAR NKGN HCGI ASFP SYPE I |
| 遺伝子ID: | 1520 |
| Uniprot: | P25774 |
| セルラーロケーション: | Lysosome |
| 計算された分子量: | 31kDa/37kDa |
| 観察された分子量: | 36kDa |
| 同義語: | CTSS |
| バックグラウンド: | The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| UniProt Protein Function: | CTSS: Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. Belongs to the peptidase C1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protease; EC 3.4.22.27 Chromosomal Location of Human Ortholog: 1q21 Cellular Component: extracellular region; extracellular space; intracellular membrane-bound organelle; lysosomal lumen; lysosome Molecular Function:collagen binding; cysteine-type endopeptidase activity; fibronectin binding; laminin binding; proteoglycan binding; serine-type endopeptidase activity Biological Process: adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen; collagen catabolic process; extracellular matrix disassembly; immune response; protein processing; proteolysis; proteolysis involved in cellular protein catabolic process; response to acidity; toll-like receptor signaling pathway |
| NCBI Summary: | The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | P25774 |
| NCBI GenInfo Identifier: | 88984046 |
| NCBI Gene ID: | 1520 |
| NCBI Accession: | P25774.3 |
| UniProt Secondary Accession: | P25774,Q5T5I0, Q6FHS5, Q9BUG3, B4DWC9, D3DV05, |
| UniProt Related Accession: | P25774 |
| Molecular Weight: | 31,626 Da |
| NCBI Full Name: | Cathepsin S |
| NCBI Synonym Full Names: | cathepsin S |
| NCBI Official Symbol: | CTSS |
| NCBI Protein Information: | cathepsin S |
| UniProt Protein Name: | Cathepsin S |
| Protein Family: | Cathepsin |
| UniProt Gene Name: | CTSS |
| UniProt Entry Name: | CATS_HUMAN |
 | Western blot analysis of extracts of mouse liver, using CTSS antibody (CAB1874) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |