Anti-CTSH Antibody (CAB5368)
- SKU:
- CAB5368
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-CTSH Antibody |
| 抗体コード: | CAB5368 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-335 of human CTSH (NP_004381.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | K-562, A-549, HT-29 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-335 of human CTSH (NP_004381.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AELC VNSL EKFH FKSW MSKH RKTY STEE YHHR LQTF ASNW RKIN AHNN GNHT FKMA LNQF SDMS FAEI KHKY LWSE PQNC SATK SNYL RGTG PYPP SVDW RKKG NFVS PVKN QGAC GSCW TFST TGAL ESAI AIAT GKML SLAE QQLV DCAQ DFNN HGCQ GGLP SQAF EYIL YNKG IMGE DTYP YQGK DGYC KFQP GKAI GFVK DVAN ITIY DEEA MVEA VALY NPVS FAFE VTQD FMMY RTGI YSST SCHK TPDK VNHA VLAV GYGE KNGI PYWI VKNS WGPQ WGMN GYFL IERG KNMC GLAA CASY PIPL V |
| 遺伝子ID: | 1512 |
| Uniprot: | P09668 |
| セルラーロケーション: | Lysosome |
| 計算された分子量: | 37kDa |
| 観察された分子量: | 32kDa |
| 同義語: | CTSH, ACC-4, ACC-5, ACC4, ACC5, CPSB |
| バックグラウンド: | The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | CTSH: Important for the overall degradation of proteins in lysosomes. Belongs to the peptidase C1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.22.16; Protease Chromosomal Location of Human Ortholog: 15q25.1 Cellular Component: cytosol; extracellular space; lysosome Molecular Function:aminopeptidase activity; caspase activator activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; HLA-A specific activating MHC class I receptor activity; peptidase activity; protein binding; serine-type endopeptidase activity Biological Process: adaptive immune response; antigen processing and presentation; cellular protein metabolic process; immune response-regulating signal transduction; membrane protein proteolysis; metanephros development; negative regulation of apoptosis; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of cell proliferation; protein destabilization; proteolysis; proteolysis involved in cellular protein catabolic process; response to retinoic acid; surfactant homeostasis; T cell mediated cytotoxicity; zymogen activation |
| NCBI Summary: | The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P09668 |
| NCBI GenInfo Identifier: | 288558851 |
| NCBI Gene ID: | 1512 |
| NCBI Accession: | P09668.4 |
| UniProt Secondary Accession: | P09668,Q96NY6, Q9BUM7, B2RBK0, |
| UniProt Related Accession: | P09668 |
| Molecular Weight: | 37,394 Da |
| NCBI Full Name: | Pro-cathepsin H |
| NCBI Synonym Full Names: | cathepsin H |
| NCBI Official Symbol: | CTSH |
| NCBI Official Synonym Symbols: | ACC4; ACC5; CPSB; ACC-4; ACC-5 |
| NCBI Protein Information: | pro-cathepsin H |
| UniProt Protein Name: | Pro-cathepsin H |
| Protein Family: | Pro-cathepsin |
| UniProt Gene Name: | CTSH |
| UniProt Entry Name: | CATH_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CTSH antibody (CAB5368) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |