Anti-CTNND2 Antibody (CAB12633)
- SKU:
- CAB12633
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CTNND2 Antibody |
| 抗体コード: | CAB12633 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 966-1225 of human CTNND2 (NP_001323.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:3000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | PC-12 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 966-1225 of human CTNND2 (NP_001323.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TLHE VITK NMEN AKAL RDAG GIEK LVGI SKSK GDKH SPKV VKAA SQVL NSMW QYRD LRSL YKKD GWSQ YHFV ASSS TIER DRQR PYSS SRTP SISP VRVS PNNR SASA PASP REMI SLKE RKTD YECT GSNA TYHG AKGE HTSR KDAM TAQN TGIS TLYR NSYG APAE DIKH NQVS AQPV PQEP SRKD YETY QPFQ NSTR NYDE SFFE DQVH HRPP ASEY TMHL GLKS TGNY VDFY SAAR PYSE LNYE TSHY PASP DSWV |
| 遺伝子ID: | 1501 |
| Uniprot: | Q9UQB3 |
| セルラーロケーション: | Cell junction, Cell projection, Nucleus, Perikaryon, adherens junction, dendrite |
| 計算された分子量: | 126kDa/132kDa |
| 観察された分子量: | 129kDa |
| 同義語: | CTNND2, GT24, NPRAP |
| バックグラウンド: | This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | CTNND2: Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain. Interacts with PDZD2. Interacts with ZBTB33. Binds to PSEN1. Interacts with RGNEF. Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain). Predominantly expressed in brain; accumulates in cortical neurons. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 5p15.2 Cellular Component: cytoplasm; perikaryon Molecular Function:beta-catenin binding; protein binding Biological Process: cell adhesion; signal transduction; synapse organization and biogenesis Disease: Cri-du-chat Syndrome |
| NCBI Summary: | This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] |
| UniProt Code: | Q9UQB3 |
| NCBI GenInfo Identifier: | 84028193 |
| NCBI Gene ID: | 1501 |
| NCBI Accession: | Q9UQB3.3 |
| UniProt Secondary Accession: | Q9UQB3,O00379, O15390, O43206, O43840, Q13589, Q9UM66 Q9UPM3, B0FTZ7, |
| UniProt Related Accession: | Q9UQB3 |
| Molecular Weight: | 126,529 Da |
| NCBI Full Name: | Catenin delta-2 |
| NCBI Synonym Full Names: | catenin delta 2 |
| NCBI Official Symbol: | CTNND2 |
| NCBI Official Synonym Symbols: | GT24; NPRAP |
| NCBI Protein Information: | catenin delta-2 |
| UniProt Protein Name: | Catenin delta-2 |
| UniProt Synonym Protein Names: | Delta-catenin; GT24; Neural plakophilin-related ARM-repeat protein; NPRAP; Neurojungin |
| Protein Family: | Catenin |
| UniProt Gene Name: | CTNND2 |
| UniProt Entry Name: | CTND2_HUMAN |
 | Western blot analysis of extracts of PC-12 cells, using CTNND2 antibody (CAB12633) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
View AllClose