Anti-CRYZ Antibody (CAB19997)[KO Validated]
![Anti-CRYZ Antibody (CAB19997)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/608x608/products/22239/22087/anti-cryz-antibody-cab19997ko-validated__32188__63793.1645805102.jpg?c=1 "Anti-CRYZ Antibody (CAB19997)[KO Validated]")
- SKU:
- CAB19997
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
![Anti-CRYZ Antibody (CAB19997)[KO Validated]](https://cdn11.bigcommerce.com/s-d5atsu6k01/images/stencil/1280x1280/products/22239/22087/anti-cryz-antibody-cab19997ko-validated__32188__63793.1645805102.jpg?c=1&imbypass=on "Anti-CRYZ Antibody (CAB19997)[KO Validated]")
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Description
| 抗体名: | Anti-CRYZ Antibody [KO Validated] |
| 抗体コード: | CAB19997 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human CRYZ. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HeLa |
| 免疫原: | Recombinant protein of human CRYZ. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 1429 |
| Uniprot: | Q08257 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 20kDa/31kDa/35kDa |
| 観察された分子量: | 35KDa |
![Anti-CRYZ Antibody [KO Validated] (CAB19997)](https://cdn11.bigcommerce.com/s-h68l9z2lnx/product_images/y/160/A19997_1__31612.jpg) | Western blot analysis of extracts from normal (control) and CRYZ knockout (KO) HeLa cells, using CRYZ antibody (CAB19997) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
| 同義語: | CRYZ |
| バックグラウンド: | Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. |
| UniProt Protein Function: | CRYZ: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.6.5.5; Oxidoreductase; RNA-binding Chromosomal Location of Human Ortholog: 1p31.1 Cellular Component: cytoplasm; cytosol Molecular Function:mRNA 3'-UTR binding; NADPH:quinone reductase activity Biological Process: protein homotetramerization; visual perception; xenobiotic catabolic process |
| NCBI Summary: | Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008] |
| UniProt Code: | Q08257 |
| NCBI GenInfo Identifier: | 585013 |
| NCBI Gene ID: | 1429 |
| NCBI Accession: | Q08257.1 |
| UniProt Secondary Accession: | Q08257,Q53FT0, Q59EU7, Q5HYE7, Q6NSK9, A6NN60, D3DQ76 |
| UniProt Related Accession: | Q08257 |
| Molecular Weight: | 31,528 Da |
| NCBI Full Name: | Quinone oxidoreductase |
| NCBI Synonym Full Names: | crystallin zeta |
| NCBI Official Symbol: | CRYZ |
| NCBI Protein Information: | quinone oxidoreductase |
| UniProt Protein Name: | Quinone oxidoreductase |
| UniProt Synonym Protein Names: | NADPH:quinone reductase; Zeta-crystallin |
| Protein Family: | Zeta-crystallin |
| UniProt Gene Name: | CRYZ |
| UniProt Entry Name: | QOR_HUMAN |