Anti-CRYM Antibody (CAB3810)
- SKU:
- CAB3810
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CRYM Antibody |
| 抗体コード: | CAB3810 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human CRYM (NP_001879.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A-549, HepG2, Jurkat, Mouse brain, Mouse kidney, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-314 of human CRYM (NP_001879.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSRV PAFL SAAE VEEH LRSS SLLI PPLE TALA NFSS GPEG GVMQ PVRT VVPV TKHR GYLG VMPA YSAA EDAL TTKL VTFY EDRG ITSV VPSH QATV LLFE PSNG TLLA VMDG NVIT AKRT AAVS AIAT KFLK PPSS EVLC ILGA GVQA YSHY EIFT EQFS FKEV RIWN RTKE NAEK FADT VQGE VRVC SSVQ EAVA GADV IITV TLAT EPIL FGEW VKPG AHIN AVGA SRPD WREL DDEL MKEA VLYV DSQE AALK ESGD VLLS GAEI FAEL GEVI KGVK PAHC EKTT VFKS LGMA VEDT VAAK LIYD SWSS GK |
| 遺伝子ID: | 1428 |
| Uniprot: | Q14894 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 33kDa |
| 観察された分子量: | 36kDa |
| 同義語: | CRYM, DFNA40, THBP |
| バックグラウンド: | Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. |
| UniProt Protein Function: | CRYM: Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors. Belongs to the ornithine cyclodeaminase family. |
| UniProt Protein Details: | Protein type:Lyase; EC 1.5.1.25 Chromosomal Location of Human Ortholog: 16p12.2 Cellular Component: mitochondrion; cytoplasm; nucleus Molecular Function:thiomorpholine-carboxylate dehydrogenase activity; protein homodimerization activity; NADP binding; transcription corepressor activity Biological Process: sensory perception of sound; negative regulation of transcription from RNA polymerase II promoter; thyroid hormone metabolic process Disease: Deafness, Autosomal Dominant 40 |
| NCBI Summary: | Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. [provided by RefSeq, Sep 2014] |
| UniProt Code: | Q14894 |
| NCBI GenInfo Identifier: | 2498259 |
| NCBI Gene ID: | 1428 |
| NCBI Accession: | Q14894.1 |
| UniProt Related Accession: | Q14894 |
| Molecular Weight: | 36kDa |
| NCBI Full Name: | Ketimine reductase mu-crystallin |
| NCBI Synonym Full Names: | crystallin mu |
| NCBI Official Symbol: | CRYM |
| NCBI Official Synonym Symbols: | THBP; DFNA40 |
| NCBI Protein Information: | ketimine reductase mu-crystallin |
| UniProt Protein Name: | Ketimine reductase mu-crystallin |
| UniProt Synonym Protein Names: | NADP-regulated thyroid-hormone-binding protein |
| Protein Family: | Ketimine reductase |
| UniProt Gene Name: | CRYM |
| UniProt Entry Name: | CRYM_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CRYM antibody (CAB3810) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Western blot analysis of extracts of rat brain, using CRYM antibody (CAB3810) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Basic Kit (RM00020)._Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded rat brain using CRYM antibody (CAB3810) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using CRYM antibody (CAB3810) at dilution of 1:100 (40x lens). |
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