Anti-CRYBA4 Antibody (CAB15268)
- SKU:
- CAB15268
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-CRYBA4 Antibody |
| 抗体コード: | CAB15268 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-196 of human CRYBA4 (NP_001877.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | 293T, HeLa |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-196 of human CRYBA4 (NP_001877.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTLQ CTKS AGPW KMVV WDED GFQG RRHE FTAE CPSV LELG FETV RSLK VLSG AWVG FEHA GFQG QQYI LERG EYPS WDAW GGNT AYPA ERLT SFRP AACA NHRD SRLT IFEQ ENFL GKKG ELSD DYPS LQAM GWEG NEVG SFHV HSGA WVCS QFPG YRGF QYVL ECDH HSGD YKHF REWG SHAP TFQV QSIR RIQQ |
| 遺伝子ID: | 1413 |
| Uniprot: | P53673 |
| セルラーロケーション: | |
| 計算された分子量: | 22kDa |
| 観察された分子量: | 22kDa |
| 同義語: | CRYBA4, CTRCT23, CYRBA4, MCOPCT4 |
| バックグラウンド: | Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, is part of a gene cluster with beta-B1, beta-B2, and beta-B3. |
| UniProt Protein Function: | CRYBA4: a major structural protein of the eye lens. A member of the beta/gamma-crystallin family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 22q12.1 Molecular Function:protein binding Biological Process: camera-type eye development; visual perception Disease: Cataract 23 |
| NCBI Summary: | Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta acidic group member, is part of a gene cluster with beta-B1, beta-B2, and beta-B3. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P53673 |
| NCBI GenInfo Identifier: | 2506318 |
| NCBI Gene ID: | 1413 |
| NCBI Accession: | P53673.3 |
| UniProt Secondary Accession: | P53673,Q4VB22, Q6ICE4, |
| UniProt Related Accession: | P53673 |
| Molecular Weight: | 22,374 Da |
| NCBI Full Name: | Beta-crystallin A4 |
| NCBI Synonym Full Names: | crystallin beta A4 |
| NCBI Official Symbol: | CRYBA4 |
| NCBI Official Synonym Symbols: | CYRBA4; CTRCT23; MCOPCT4 |
| NCBI Protein Information: | beta-crystallin A4 |
| UniProt Protein Name: | Beta-crystallin A4 |
| UniProt Synonym Protein Names: | Beta-A4 crystallin |
| Protein Family: | Beta-crystallin |
| UniProt Gene Name: | CRYBA4 |
| UniProt Entry Name: | CRBA4_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CRYBA4 antibody (CAB15268) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30S. |
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