Anti-CRLF2 Antibody (CAB10152)
- SKU:
- CAB10152
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-CRLF2 Antibody |
抗体コード: | CAB10152 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-231 of human CRLF2 (NP_071431.2). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:1000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T, Jurkat, Mouse liver, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 23-231 of human CRLF2 (NP_071431.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | QGGA AEGV QIQI IYFN LETV QVTW NASK YSRT NLTF HYRF NGDE AYDQ CTNY LLQE GHTS GCLL DAEQ RDDI LYFS IRNG THPV FTAS RWMV YYLK PSSP KHVR FSWH QDAV TVTC SDLS YGDL LYEV QYRS PFDT EWQS KQEN TCNV TIEG LDAE KCYS FWVR VKAM EDVY GPDT YPSD WSEV TCWQ RGEI RDAC AETP TPPK PKLS K |
遺伝子ID: | 64109 |
Uniprot: | Q9HC73 |
セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein |
計算された分子量: | 26kDa/29kDa/42kDa |
観察された分子量: | 50kDa |
同義語: | CRLF2, CRL2, CRLF2Y, TSLPR |
バックグラウンド: | This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. |
UniProt Protein Function: | CRLF2: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system. Belongs to the type I cytokine receptor family. Type 5 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: Xp22.33 and Yp11.2 |
NCBI Summary: | This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014] |
UniProt Code: | Q9HC73 |
NCBI GenInfo Identifier: | 38257768 |
NCBI Gene ID: | 64109 |
NCBI Accession: | Q9HC73.1 |
UniProt Secondary Accession: | Q9HC73,Q5G7M1, Q9H5R3, J3QKD1, |
UniProt Related Accession: | Q9HC73 |
Molecular Weight: | 29,360 Da |
NCBI Full Name: | Cytokine receptor-like factor 2 |
NCBI Synonym Full Names: | cytokine receptor-like factor 2 |
NCBI Official Symbol: | CRLF2 |
NCBI Official Synonym Symbols: | CRL2; TSLPR; CRLF2Y |
NCBI Protein Information: | cytokine receptor-like factor 2 |
UniProt Protein Name: | Cytokine receptor-like factor 2 |
UniProt Synonym Protein Names: | Cytokine receptor-like 2; IL-XR; Thymic stromal lymphopoietin protein receptor; TSLP receptor |
Protein Family: | Thymic stromal lymphopoietin |
UniProt Gene Name: | CRLF2 |
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