Anti-CRHR1 Antibody (CAB8409)
- SKU:
- CAB8409
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-CRHR1 Antibody |
抗体コード: | CAB8409 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-120 of human CRHR1 (NP_001138618.1). |
申し込み: | WB IHC |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-87MG, SH-SY5Y, HT-29, HeLa, Mouse brain, Mouse liver, Mouse testis, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-120 of human CRHR1 (NP_001138618.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SLQD QHCE SLSL ASNI SGLQ CNAS VDLI GTCW PRSP AGQL VVRP CPAF FYGV RYNT TNNG YREC LANG SWAA RVNY SECQ EILN EEKK SKVH YHVA V |
遺伝子ID: | 1394 |
Uniprot: | P34998 |
セルラーロケーション: | Cell membrane, Endosome, Multi-pass membrane protein |
計算された分子量: | 28kDa/43kDa/46kDa/47kDa/50kDa |
観察された分子量: | 60kDa |
同義語: | CRHR1, CRF-R, CRF-R-1, CRF-R1, CRF1, CRFR-1, CRFR1, CRH-R-1, CRH-R1, CRHR, CRHR1L |
バックグラウンド: | This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. |
UniProt Protein Function: | CRF-R1: a G-protein coupled receptor that specifically binds corticotropin-releasing hormone, a potent mediator of endocrine, autonomic, behavioral, and immune responses to stress. Four splice-variant isoforms have been described. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 2 Chromosomal Location of Human Ortholog: 17q21.31 Cellular Component: integral to membrane; integral to plasma membrane; intrinsic to plasma membrane; plasma membrane Molecular Function:corticotrophin-releasing factor receptor activity; protein binding Biological Process: adenylate cyclase activation; adrenocorticotropin hormone secretion; immune response; parturition |
NCBI Summary: | This locus represents naturally occurring readthrough transcription between neighboring GeneID:401884 (ADP-ribosylation factor 3 pseudogene) and GeneID:1394 (CRHR1, corticotropin releasing hormone receptor 1) on chromosome 17. The readthrough transcript encodes a protein that shares sequence identity with the product of the CRHR1 gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
UniProt Code: | P34998 |
NCBI GenInfo Identifier: | 461836 |
NCBI Gene ID: | 104909134 |
NCBI Accession: | P34998.1 |
UniProt Secondary Accession: | P34998,Q13008, Q4QRJ1, Q9UK64, B4DIE9, |
Molecular Weight: | 28,122 Da |
NCBI Full Name: | Corticotropin-releasing factor receptor 1 |
NCBI Official Symbol: | MGC57346-CRHR1 |
NCBI Protein Information: | MGC57346-CRHR1 protein |
UniProt Protein Name: | Corticotropin-releasing factor receptor 1 |
UniProt Synonym Protein Names: | Corticotropin-releasing hormone receptor 1; CRH-R-1; CRH-R1 |
Protein Family: | Corticotropin-releasing factor receptor |
UniProt Gene Name: | CRHR1 |
UniProt Entry Name: | CRFR1_HUMAN |
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