Anti-CRELD1 Antibody (CAB15186)
- SKU:
- CAB15186
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CRELD1 Antibody |
| 抗体コード: | CAB15186 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CRELD1 (NP_056328.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse lung |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CRELD1 (NP_056328.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RGLV DSFN KGLE RTIR DNFG GGNT AWEE ENLS KYKD SETR LVEV LEGV CSKS DFEC HRLL ELSE ELVE SWWF HKQQ EAPD LFQW LCSD SLKL CCPA GTFG P |
| 遺伝子ID: | 78987 |
| Uniprot: | Q96HD1 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 45kDa |
| 観察された分子量: | 53kDa |
| 同義語: | CRELD1, AVSD2, CIRRIN |
| バックグラウンド: | This gene encodes a member of a subfamily of epidermal growth factor-related proteins. The encoded protein is characterized by a cysteine-rich with epidermal growth factor-like domain. This protein may function as a cell adhesion molecule. Mutations in this gene are the cause of atrioventricular septal defect. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | CRELD1: Defects in CRELD1 may be the cause of susceptibility to atrioventricular septal defect type 2 (AVSD2). AVSD is a spectrum of cardiac malformations that result in a persistent common atrioventricular canal. The complete form of AVSD involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum. A less severe form, known as partial AVSD or ostium primum atrial septal defect has a deficiency of the atrial septum. Complete AVSD are clinically apparent at birth, whereas less severe forms, such as an isolated cleft mitral valve or small defects of the atrial or ventricular septa may go undetected. Belongs to the CRELD family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Cell adhesion Chromosomal Location of Human Ortholog: 3p25.3 Cellular Component: integral to membrane Molecular Function:calcium ion binding Disease: Atrioventricular Septal Defect, Susceptibility To, 2 |
| NCBI Summary: | This gene encodes a member of a subfamily of epidermal growth factor-related proteins. The encoded protein is characterized by a cysteine-rich with epidermal growth factor-like domain. This protein may function as a cell adhesion molecule. Mutations in this gene are the cause of atrioventricular septal defect. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010] |
| UniProt Code: | Q96HD1 |
| NCBI GenInfo Identifier: | 209572751 |
| NCBI Gene ID: | 78987 |
| NCBI Accession: | Q96HD1.3 |
| UniProt Secondary Accession: | Q96HD1,Q6I9X5, Q8NFT4, Q9Y409, A8MX90, B2RAA9, |
| UniProt Related Accession: | Q96HD1 |
| Molecular Weight: | 45,942 Da |
| NCBI Full Name: | Cysteine-rich with EGF-like domain protein 1 |
| NCBI Synonym Full Names: | cysteine-rich with EGF-like domains 1 |
| NCBI Official Symbol: | CRELD1 |
| NCBI Official Synonym Symbols: | AVSD2; CIRRIN |
| NCBI Protein Information: | cysteine-rich with EGF-like domain protein 1 |
| UniProt Protein Name: | Cysteine-rich with EGF-like domain protein 1 |
| Protein Family: | Cysteine-rich with EGF-like domain protein |
| UniProt Gene Name: | CRELD1 |
| UniProt Entry Name: | CREL1_HUMAN |
 | Western blot analysis of extracts of Mouse lung, using CRELD1 antibody (CAB15186) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s. |
 | Immunofluorescence analysis of C6 cells using CRELD1 antibody (CAB15186) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using CRELD1 antibody (CAB15186) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of L929 cells using CRELD1 antibody (CAB15186) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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