Anti-CREB3L3 Antibody (CAB16655)
- SKU:
- CAB16655
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-CREB3L3 Antibody |
| 抗体コード: | CAB16655 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 371-460 of human CREB3L3 (NP_001258924.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | HepG2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 371-460 of human CREB3L3 (NP_001258924.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AADA VPGS EAPG PRPE ADTT REES PGSP GADW GFQD TANL TNST EELD NATL VLRN ATEG LGQV ALLD WVAP GPST GSGR AGLE AAGD EL |
| 遺伝子ID: | 84699 |
| Uniprot: | Q68CJ9 |
| セルラーロケーション: | |
| 計算された分子量: | 35kDa/48kDa/49kDa |
| 観察された分子量: | 70KDa |
| 同義語: | CREB3L3, CREB-H, CREBH, HYST1481 |
| バックグラウンド: | This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CREB3L3: Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Belongs to the bZIP family. ATF subfamily. Binds DNA as a dimer. Probably homodimerizes. Probably forms a heterodimer with ATF6. Interacts with ATF6. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transcription factor Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: endoplasmic reticulum; membrane; nucleus Molecular Function:protein binding; protein heterodimerization activity; protein homodimerization activity Biological Process: positive regulation of transcription from RNA polymerase II promoter |
| NCBI Summary: | This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q68CJ9 |
| NCBI GenInfo Identifier: | 148886847 |
| NCBI Gene ID: | 84699 |
| NCBI Accession: | Q68CJ9.2 |
| UniProt Secondary Accession: | Q68CJ9,Q6ZMC5, Q96TB9, B2R7S6, B7ZL69, M0QYW7, |
| UniProt Related Accession: | Q68CJ9 |
| Molecular Weight: | 35,845 Da |
| NCBI Full Name: | Cyclic AMP-responsive element-binding protein 3-like protein 3 |
| NCBI Synonym Full Names: | cAMP responsive element binding protein 3 like 3 |
| NCBI Official Symbol: | CREB3L3 |
| NCBI Official Synonym Symbols: | CREBH; CREB-H; HYST1481 |
| NCBI Protein Information: | cyclic AMP-responsive element-binding protein 3-like protein 3 |
| UniProt Protein Name: | Cyclic AMP-responsive element-binding protein 3-like protein 3 |
| UniProt Synonym Protein Names: | Transcription factor CREB-H |
| Protein Family: | Cyclic AMP-responsive element-binding protein 3-like protein |
| UniProt Gene Name: | CREB3L3 |
| UniProt Entry Name: | CR3L3_HUMAN |
 | Western blot analysis of extracts of HepG2 cells, using CREB3L3 antibody (CAB16655) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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