Anti-COX7A2L Antibody (CAB8298)
- SKU:
- CAB8298
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | COX7A2L Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8298 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human COX7A2L (NP_004709.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, A-549, HeLa, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-114 of human COX7A2L (NP_004709.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MYYK FSGF TQKL AGAW ASEA YSPQ GLKP VVST EAPP IIFA TPTK LTSD STVY DYAG KNKV PELQ KFFQ KADG VPVY LKRG LPDQ MLYR TTMA LTVG GTIY CLIA LYMA SQPK NK |
| 遺伝子ID: | 9167 |
| Uniprot: | O14548 |
| セルラーロケーション: | Mitochondrion inner membrane |
| 計算された分子量: | 12kDa |
| 観察された分子量: | 13kDa |
| 同義語: | COX7A2L, COX7AR, COX7RP, EB1, SIG81 |
| バックグラウンド: | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. |
| UniProt Protein Function: | COX7A2L: May be a regulatory subunit of cytochrome c oxidase that mediates the higher level of energy production in target cells by estrogen. Belongs to the cytochrome c oxidase VIIa family. |
| UniProt Protein Details: | Protein type:Oxidoreductase; Mitochondrial; Energy Metabolism - oxidative phosphorylation Chromosomal Location of Human Ortholog: 2p21 Cellular Component: mitochondrial inner membrane Biological Process: mitochondrial electron transport, cytochrome c to oxygen |
| NCBI Summary: | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016] |
| UniProt Code: | O14548 |
| NCBI GenInfo Identifier: | 20141187 |
| NCBI Gene ID: | 9167 |
| NCBI Accession: | O14548.2 |
| UniProt Secondary Accession: | O14548,Q9P118, |
| UniProt Related Accession: | O14548 |
| Molecular Weight: | 12,615 Da |
| NCBI Full Name: | Cytochrome c oxidase subunit 7A-related protein, mitochondrial |
| NCBI Synonym Full Names: | cytochrome c oxidase subunit 7A2 like |
| NCBI Official Symbol: | COX7A2L |
| NCBI Official Synonym Symbols: | EB1; SIG81; COX7AR; COX7RP |
| NCBI Protein Information: | cytochrome c oxidase subunit 7A-related protein, mitochondrial |
| UniProt Protein Name: | Cytochrome c oxidase subunit 7A-related protein, mitochondrial |
| UniProt Synonym Protein Names: | COX7a-related protein; Cytochrome c oxidase subunit VIIa-related protein; EB1 |
| Protein Family: | Cytochrome c oxidase subunit 7A-related protein |
| UniProt Gene Name: | COX7A2L |
| UniProt Entry Name: | COX7R_HUMAN |
 | Western blot analysis of extracts of various cell lines, using COX7A2L antibody (CAB8298) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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