Anti-COX11 Antibody (CAB16290)
- SKU:
- CAB16290
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-COX11 Antibody |
| 抗体コード: | CAB16290 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human COX11 (NP_004366.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 140-240 of human COX11 (NP_004366.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ENMV PVKD RIIK ISFN ADVH ASLQ WNFR PQQT EIYV VPGE TALA FYRA KNPT DKPV IGIS TYNI VPFE AGQY FNKI QCFC FEEQ RLNP QEEV DMPV FFYI D |
| 遺伝子ID: | 1353 |
| Uniprot: | Q9Y6N1 |
| セルラーロケーション: | Intermembrane side, Mitochondrion inner membrane, Single-pass membrane protein |
| 計算された分子量: | 26kDa/31kDa |
| 観察された分子量: |
| 同義語: | COX11, COX11P |
| バックグラウンド: | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. |
| UniProt Protein Function: | COX11: Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. Belongs to the COX11/CtaG family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Oxidoreductase; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral Chromosomal Location of Human Ortholog: 17q22 Cellular Component: mitochondrion Molecular Function:cytochrome-c oxidase activity; electron carrier activity Biological Process: respiratory chain complex IV assembly; respiratory gaseous exchange |
| NCBI Summary: | Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX. This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene has been found on chromosome 6. [provided by RefSeq, Jun 2009] |
| UniProt Code: | Q9Y6N1 |
| NCBI GenInfo Identifier: | 60416378 |
| NCBI Gene ID: | 1353 |
| NCBI Accession: | Q9Y6N1.3 |
| UniProt Secondary Accession: | Q9Y6N1,Q6FHB7, Q9BRX0, Q9UME8, D3DTY5, I3L220, |
| UniProt Related Accession: | Q9Y6N1 |
| Molecular Weight: | 26,133 Da |
| NCBI Full Name: | Cytochrome c oxidase assembly protein COX11, mitochondrial |
| NCBI Synonym Full Names: | COX11, cytochrome c oxidase copper chaperone |
| NCBI Official Symbol: | COX11 |
| NCBI Official Synonym Symbols: | COX11P |
| NCBI Protein Information: | cytochrome c oxidase assembly protein COX11, mitochondrial |
| UniProt Protein Name: | Cytochrome c oxidase assembly protein COX11, mitochondrial |
| Protein Family: | Cytochrome c oxidase assembly protein |
| UniProt Gene Name: | COX11 |
| UniProt Entry Name: | COX11_HUMAN |
 | Western blot analysis of extracts of various cell lines, using COX11 antibody (CAB16290) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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