Anti-COX IV Antibody (CAB1263)
- SKU:
- CAB1263
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-COX IV Antibody |
| 抗体コード: | CAB1263 |
| 抗体サイズ: | 100µL |
| 申し込み: | WB IHC IF IP FC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human COX IV |
| 申し込み: | WB IHC IF IP FC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:20 - 1:50 IP 1:20 - 1:50 FC 1:20 - 1:50 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7 |
| 免疫原: | Recombinant protein of human COX IV |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 1327 |
| Uniprot: | P13073 |
| セルラーロケーション: | Mitochondrion inner membrane |
| 計算された分子量: | 19kDa |
| 観察された分子量: | 20kDa |
| 同義語: | COX4I1, COX IV-1, COX4, COX4-1, COXIV, COXIV-1, COX IV |
| バックグラウンド: | Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | COX4I1: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Ubiquitous. Belongs to the cytochrome c oxidase IV family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Mitochondrial; EC 1.9.3.1; Oxidoreductase Chromosomal Location of Human Ortholog: 16q24.1 Cellular Component: membrane; mitochondrial inner membrane; mitochondrial respiratory chain complex IV; mitochondrion; nucleus Molecular Function:protein binding Biological Process: generation of precursor metabolites and energy; mitochondrial electron transport, cytochrome c to oxygen |
| NCBI Summary: | Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Pseudogenes related to this gene are located on chromosomes 13 and 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P13073 |
| NCBI GenInfo Identifier: | 117086 |
| NCBI Gene ID: | 1327 |
| NCBI Accession: | P13073.1 |
| UniProt Secondary Accession: | P13073,Q6P666, B2R4J2, D3DUM7, |
| UniProt Related Accession: | P13073 |
| Molecular Weight: | 19,577 Da |
| NCBI Full Name: | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial |
| NCBI Synonym Full Names: | cytochrome c oxidase subunit 4I1 |
| NCBI Official Symbol: | COX4I1 |
| NCBI Official Synonym Symbols: | COX4; COXIV; COX4-1; COXIV-1; COX IV-1 |
| NCBI Protein Information: | cytochrome c oxidase subunit 4 isoform 1, mitochondrial |
| UniProt Protein Name: | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial |
| UniProt Synonym Protein Names: | Cytochrome c oxidase polypeptide IV; Cytochrome c oxidase subunit IV isoform 1; COX IV-1 |
| Protein Family: | Cytochrome c oxidase |
| UniProt Gene Name: | COX4I1 |
| UniProt Entry Name: | COX41_HUMAN |
 | Western blot analysis of extracts of MCF-7 cells, using COX IV antibody (CAB1263). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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