Anti-COPZ1 Antibody (CAB12148)
- SKU:
- CAB12148
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-COPZ1 Antibody |
| 抗体コード: | CAB12148 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-177 of human COPZ1 (NP_057141.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HT-29, LO2, HeLa, Mouse kidney, Mouse testis, Mouse spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-177 of human COPZ1 (NP_057141.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MEAL ILEP SLYT VKAI LILD NDGD RLFA KYYD DTYP SVKE QKAF EKNI FNKT HRTD SEIA LLEG LTVV YKSS IDLY FYVI GSSY ENEL MLMA VLNC LFDS LSQM LRKN VEKR ALLE NMEG LFLA VDEI VDGG VILE SDPQ QVVH RVAL RGED VPLT EQTV SQVL QSAK EQIK WSLL R |
| 遺伝子ID: | 22818 |
| Uniprot: | P61923 |
| セルラーロケーション: | COPI-coated vesicle membrane, Cytoplasm, Cytoplasmic side, Cytoplasmic vesicle, Golgi apparatus membrane, Peripheral membrane protein |
| 計算された分子量: | 14kDa/17kDa/18kDa/20kDa/21kDa |
| 観察された分子量: | 19kDa |
| 同義語: | COPZ1, CGI-120, COPZ, HSPC181, zeta-COP, zeta1-COP |
| バックグラウンド: | This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | COPZ1: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the adaptor complexes small subunit family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12q13.13 Cellular Component: COPI vesicle coat; cytosol; endoplasmic reticulum membrane; Golgi membrane; transport vesicle Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to ER |
| NCBI Summary: | This gene encodes a subunit of the cytoplasmic coatamer protein complex, which is involved in autophagy and intracellular protein trafficking. The coatomer protein complex is comprised of seven subunits and functions as the coat protein of coat protein complex (COP)I-vesicles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012] |
| UniProt Code: | P61923 |
| NCBI GenInfo Identifier: | 48428830 |
| NCBI Gene ID: | 22818 |
| NCBI Accession: | P61923.1 |
| UniProt Secondary Accession: | P61923,Q549N6, Q9Y3C3, B4DDX8, B4DHZ0, F8VS17, F8VWL5 |
| UniProt Related Accession: | P61923 |
| Molecular Weight: | 20kDa |
| NCBI Full Name: | Coatomer subunit zeta-1 |
| NCBI Synonym Full Names: | coatomer protein complex subunit zeta 1 |
| NCBI Official Symbol: | COPZ1 |
| NCBI Official Synonym Symbols: | COPZ; CGI-120; HSPC181; zeta-COP; zeta1-COP |
| NCBI Protein Information: | coatomer subunit zeta-1 |
| UniProt Protein Name: | Coatomer subunit zeta-1 |
| UniProt Synonym Protein Names: | Zeta-1-coat protein; Zeta-1 COP |
| Protein Family: | Coatomer |
| UniProt Gene Name: | COPZ1 |
 | Western blot analysis of extracts of various cell lines, using COPZ1 antibody (CAB12148) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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