Anti-COPS6 Antibody (CAB7072)
- SKU:
- CAB7072
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
抗体名: | Anti-COPS6 Antibody |
抗体コード: | CAB7072 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 58-327 of human COPS6 (NP_006824.2). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | MCF7, Jurkat, Mouse heart, Mouse brain, Mouse liver, Rat liver, Rat brain |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 58-327 of human COPS6 (NP_006824.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MRSQ EGRP VQVI GALI GKQE GRNI EVMN SFEL LSHT VEEK IIID KEYY YTKE EQFK QVFK ELEF LGWY TTGG PPDP SDIH VHKQ VCEI IESP LFLK LNPM TKHT DLPV SVFE SVID IING EATM LFAE LTYT LATE EAER IGVD HVAR MTAT GSGE NSTV AEHL IAQH SAIK MLHS RVKL ILEY VKAS EAGE VPFN HEIL REAY ALCH CLPV LSTD KFKT DFYD QCND VGLM AYLG TITK TCNT MNQF VNKF NVLY DRQG IGRR MRGL FF |
遺伝子ID: | 10980 |
Uniprot: | Q7L5N1 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 36kDa |
観察された分子量: | 36kDa |
同義語: | COPS6, CSN6, MOV34-34KD |
バックグラウンド: | The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. |
UniProt Protein Function: | COPS6: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor- responsive activity. Stabilizes RFWD2/COP1 through reducing RFWD2 auto-ubiquitination and decelerating RFWD2 turnover rate, hence regulates the ubiquitination of RFWD2 targets. Belongs to the peptidase M67A family. CSN6 subfamily. |
UniProt Protein Details: | Protein type:Cell cycle regulation Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: nucleoplasm; signalosome; cytoplasm Molecular Function:protein binding Biological Process: cullin deneddylation; viral reproduction |
NCBI Summary: | The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q7L5N1 |
NCBI GenInfo Identifier: | 55976470 |
NCBI Gene ID: | 10980 |
NCBI Accession: | Q7L5N1.1 |
UniProt Secondary Accession: | Q7L5N1,O15387, A4D2A3, |
UniProt Related Accession: | Q7L5N1 |
Molecular Weight: | 327 |
NCBI Full Name: | COP9 signalosome complex subunit 6 |
NCBI Synonym Full Names: | COP9 signalosome subunit 6 |
NCBI Official Symbol: | COPS6 |
NCBI Official Synonym Symbols: | CSN6; MOV34-34KD |
NCBI Protein Information: | COP9 signalosome complex subunit 6; SGN6; hVIP; H_NH0506M12.12; MOV34 homolog, 34 kD; signalosome subunit 6; vpr-interacting protein; COP9 subunit 6 (MOV34 homolog, 34 kD); JAB1-containing signalosome subunit 6; COP9 constitutive photomorphogenic homolog subunit 6 |
UniProt Protein Name: | COP9 signalosome complex subunit 6 |
UniProt Synonym Protein Names: | JAB1-containing signalosome subunit 6; MOV34 homolog; Vpr-interacting protein; hVIP |
UniProt Gene Name: | COPS6 |
UniProt Entry Name: | CSN6_HUMAN |
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