Anti-COL5A1 Antibody (CAB1515)
- SKU:
- CAB1515
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-COL5A1 Antibody |
| 抗体コード: | CAB1515 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 20-120 of human COL5A1 (NP_000084.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse lung |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 20-120 of human COL5A1 (NP_000084.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LPPL LLLL LWAP PPSR AAQP ADLL KVLD FHNL PDGI TKTT GFCA TRRS SKGP DVAY RVTK DAQL SAPT KQLY PASA FPED FSIL TTVK AKKG SQAF LVSI Y |
| 遺伝子ID: | 1289 |
| Uniprot: | P20908 |
| セルラーロケーション: | Secreted, extracellular matrix, extracellular space |
| 計算された分子量: | 183kDa |
| 観察された分子量: | 180kDa |
| 同義語: | COL5A1, EDSC |
| バックグラウンド: | This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. |
| UniProt Protein Function: | COL5A1: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis or severe classic type Ehlers-Danlos syndrome. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type 2 (EDS2); also known as Ehlers-Danlos syndrome mitis or mild classic type Ehlers Danlos syndrome. Belongs to the fibrillar collagen family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Cell adhesion; Secreted, signal peptide; Extracellular matrix Chromosomal Location of Human Ortholog: 9q34.2-q34.3 Cellular Component: extracellular matrix; collagen type V; endoplasmic reticulum lumen; extracellular region; basement membrane Molecular Function:heparin binding; integrin binding; proteoglycan binding; platelet-derived growth factor binding; extracellular matrix structural constituent; metal ion binding Biological Process: skin development; heart morphogenesis; blood vessel development; axon guidance; extracellular matrix organization and biogenesis; cell migration; collagen fibril organization; extracellular matrix disassembly; collagen catabolic process; integrin biosynthetic process; regulation of cellular component organization and biogenesis; fibril organization and biogenesis; cell adhesion; collagen biosynthetic process; eye morphogenesis; wound healing, spreading of epidermal cells Disease: Ehlers-danlos Syndrome, Type I |
| NCBI Summary: | This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013] |
| UniProt Code: | P20908 |
| NCBI GenInfo Identifier: | 89276751 |
| NCBI Gene ID: | 1289 |
| NCBI Accession: | NP_000084.3 |
| UniProt Secondary Accession: | P20908,Q15094, Q5SUX4, |
| UniProt Related Accession: | P20908 |
| Molecular Weight: | 183,560 Da |
| NCBI Full Name: | collagen alpha-1(V) chain isoform 1 preproprotein |
| NCBI Synonym Full Names: | collagen, type V, alpha 1 |
| NCBI Official Symbol: | COL5A1 |
| NCBI Protein Information: | collagen alpha-1(V) chain; collagen alpha-1(V) chain |
| UniProt Protein Name: | Collagen alpha-1(V) chain |
| Protein Family: | Collagen |
| UniProt Gene Name: | COL5A1 |
| UniProt Entry Name: | CO5A1_HUMAN |
 | Western blot analysis of extracts of mouse lung, using COL5A1 antibody (CAB1515) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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