Anti-COL4A2 Antibody (CAB7657)
- SKU:
- CAB7657
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-COL4A2 Antibody |
| 抗体コード: | CAB7657 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1486-1712 of human COL4A2 (NP_001837.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | NCI-H460, HeLa, Mouse lung, Mouse ovary, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1486-1712 of human COL4A2 (NP_001837.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VSIG YLLV KHSQ TDQE PMCP VGMN KLWS GYSL LYFE GQEK AHNQ DLGL AGSC LARF STMP FLYC NPGD VCYY ASRN DKSY WLST TAPL PMMP VAED EIKP YISR CSVC EAPA IAIA VHSQ DVSI PHCP AGWR SLWI GYSF LMHT AAGD EGGG QSLV SPGS CLED FRAT PFIE CNGG RGTC HYYA NKYS FWLT TIPE QSFQ GSPS ADTL KAGL IRTH ISRC QVCM KNL |
| 遺伝子ID: | 1284 |
| Uniprot: | P08572 |
| セルラーロケーション: | Secreted, basement membrane, extracellular matrix, extracellular space |
| 計算された分子量: | 167kDa |
| 観察された分子量: | 200kDa |
| 同義語: | COL4A2, ICH, POREN2 |
| バックグラウンド: | This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. |
| UniProt Protein Function: | COL4A2: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Defects in COL4A2 are the cause of porencephaly type 2 (POREN2). POREN2 is a neurologic disorder characterized by a fluid-filled cysts or cavities within the cerebral hemispheres. Affected individuals typically have hemiplegia, seizures, and intellectual disability. Porencephaly type 2, or schizencephalic porencephaly, is usually symmetric and represents a primary defect in the development of the cerebral ventricles. Defects in COL4A2 are a cause of susceptibility to intracerebral hemorrhage (ICH). ICH is a pathological condition characterized by bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. Intracerebral bleeding is a common cause of stroke. Belongs to the type IV collagen family. |
| UniProt Protein Details: | Protein type:Secreted; Extracellular matrix; Secreted, signal peptide Chromosomal Location of Human Ortholog: 13q34 Cellular Component: extracellular matrix; intracellular membrane-bound organelle; endoplasmic reticulum lumen; collagen type IV; extracellular region Molecular Function:protein binding; extracellular matrix structural constituent Biological Process: axon guidance; collagen catabolic process; extracellular matrix disassembly; receptor-mediated endocytosis; negative regulation of angiogenesis; extracellular matrix organization and biogenesis; transcription, DNA-dependent; angiogenesis Disease: Porencephaly 2; Hemorrhage, Intracerebral, Susceptibility To |
| NCBI Summary: | This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08572 |
| NCBI GenInfo Identifier: | 116256354 |
| NCBI Gene ID: | 1284 |
| NCBI Accession: | NP_001837.2 |
| UniProt Secondary Accession: | P08572,Q14052, Q548C3, Q5VZA9, Q66K23, |
| UniProt Related Accession: | P08572 |
| Molecular Weight: | 167,553 Da |
| NCBI Full Name: | collagen alpha-2(IV) chain preproprotein |
| NCBI Synonym Full Names: | collagen, type IV, alpha 2 |
| NCBI Official Symbol: | COL4A2 |
| NCBI Official Synonym Symbols: | ICH; POREN2 |
| NCBI Protein Information: | collagen alpha-2(IV) chain; collagen alpha-2(IV) chain; canstatin |
| UniProt Protein Name: | Collagen alpha-2(IV) chain |
| Protein Family: | Collagen |
| UniProt Gene Name: | COL4A2 |
| UniProt Entry Name: | CO4A2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using COL4A2 antibody (CAB7657) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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