Anti-COG6 Antibody (CAB10319)
- SKU:
- CAB10319
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-COG6 Antibody |
| 抗体コード: | CAB10319 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 508-657 of human COG6 (NP_065802.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Jurkat, A-549, U-87MG, Mouse kidney, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 508-657 of human COG6 (NP_065802.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MKTT LALF EFTD RRLE MLQF QIEA HLDT LINE QASY VLTR VGLS YIYN TVQQ HKPE QGSL ANMP NLDS VTLK AAMV QFDR YLSA PDNL LIPQ LNFL LSAT VKEQ IVKQ STEL VCRA YGEV YAAV MNPI NEYK DPEN ILHR SPQQ VQTL LS |
| 遺伝子ID: | 57511 |
| Uniprot: | Q9Y2V7 |
| セルラーロケーション: | Golgi apparatus membrane, Peripheral membrane protein |
| 計算された分子量: | 7kDa/68kDa/73kDa |
| 観察された分子量: | 73kDa |
| 同義語: | COG6, CDG2L, COD2, SHNS |
| バックグラウンド: | This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | COG6: Required for normal Golgi function. Defects in COG6 are the cause of congenital disorder of glycosylation type 2L (CDG2L). CDG2L is a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Clinical features of CDG2L include neonatal intractable focal seizures, vomiting, loss of consciousness, intracranial bleeding due to vitamin K deficiency, and death in infancy. Belongs to the COG6 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 13q14.11 Cellular Component: Golgi membrane; Golgi transport complex; trans-Golgi network membrane Molecular Function:protein binding Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport Disease: Congenital Disorder Of Glycosylation, Type Iil; Shaheen Syndrome |
| NCBI Summary: | This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi apparatus. The encoded protein is organized with conserved oligomeric Golgi complex components 5, 7 and 8 into a sub-complex referred to as lobe B. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009] |
| UniProt Code: | Q9Y2V7 |
| NCBI GenInfo Identifier: | 182676410 |
| NCBI Gene ID: | 57511 |
| NCBI Accession: | Q9Y2V7.2 |
| UniProt Secondary Accession: | Q9Y2V7,Q5T0U1, Q6AI19, Q86V49, Q9ULT5, |
| UniProt Related Accession: | Q9Y2V7 |
| Molecular Weight: | 73kDa |
| NCBI Full Name: | Conserved oligomeric Golgi complex subunit 6 |
| NCBI Synonym Full Names: | component of oligomeric golgi complex 6 |
| NCBI Official Symbol: | COG6 |
| NCBI Official Synonym Symbols: | COD2; SHNS; CDG2L |
| NCBI Protein Information: | conserved oligomeric Golgi complex subunit 6 |
| UniProt Protein Name: | Conserved oligomeric Golgi complex subunit 6 |
| UniProt Synonym Protein Names: | Component of oligomeric Golgi complex 6 |
| Protein Family: | Conserved oligomeric Golgi complex |
| UniProt Gene Name: | COG6 |
 | Western blot analysis of extracts of various cell lines, using COG6 antibody (CAB10319) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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