Anti-COG2 抗体 (CAB6251)

抗体名:	Anti-COG2 Antibody
抗体コード:	CAB6251
抗体サイズ:	20uL, 50uL, 100uL
申し込み:	WB IHC IF
反応性:	Human, Mouse, Rat
宿主種:	Rabbit
免疫原:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human COG2 (NP_031383.1).

申し込み:	WB IHC IF
推奨希釈:	WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100
反応性:	Human, Mouse, Rat
ポジティブサンプル:	SW620, HepG2, MCF7, Mouse kidney, Rat testis, Rat stomach

免疫原:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human COG2 (NP_031383.1).
精製方法:	Affinity purification
ストレージバッファ:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:	IgG
順序:	MEKS RMNL PKGP DTLC FDKD EFMK EDFD VDHF VSDC RKRV QLEE LRDD LELY YKLL KTAM VELI NKDY ADFV NLST NLVG MDKA LNQL SVPL GQLR EEVL SLRS SVSE GIRA VDER MSKQ EDIR KKKM CVLR LIQV IRSV EKIE KILN SQSS KETS ALEA SSPL LTGQ ILER IATE FNQL QFHA VQSK GMPL LDKV RPRI AGIT AMLQ QSLE GLLL EGLQ TSDV DIIR HCLR TYAT IDKT RDAE ALVG QVLV KPYI DEVI IEQF VESH PNGL QVMY NKLL
遺伝子ID:	22796
Uniprot:	Q14746
セルラーロケーション:	Cytoplasmic side, Golgi apparatus membrane, Peripheral membrane protein
計算された分子量:	83kDa
観察された分子量:	88kDa

同義語:

COG2, LDLC, CDG2Q

バックグラウンド:

This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.

UniProt Protein Function:	COG2: Required for normal Golgi morphology and function. Belongs to the COG2 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Chromosomal Location of Human Ortholog: 1q42.2 Cellular Component: Golgi membrane; Golgi stack; Golgi transport complex; cytosol Molecular Function:protein binding; protein complex binding; protein transporter activity Biological Process: intracellular protein transport; intra-Golgi vesicle-mediated transport; oligosaccharide biosynthetic process; protein amino acid glycosylation; Golgi organization and biogenesis
NCBI Summary:	This gene encodes a subunit of the conserved oligomeric Golgi complex that is required for maintaining normal structure and activity of the Golgi complex. The encoded protein specifically interacts with the USO1 vesicle docking protein and may be necessary for normal Golgi ribbon formation and trafficking of Golgi enzymes. Mutations of this gene are associated with abnormal glycosylation within the Golgi apparatus. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
UniProt Code:	Q14746
NCBI GenInfo Identifier:	2498512
NCBI Gene ID:	22796
NCBI Accession:	Q14746.1
UniProt Secondary Accession:	Q14746,Q86U99,
UniProt Related Accession:	Q14746
Molecular Weight:	738
NCBI Full Name:	Conserved oligomeric Golgi complex subunit 2
NCBI Synonym Full Names:	component of oligomeric golgi complex 2
NCBI Official Symbol:	COG2
NCBI Official Synonym Symbols:	LDLC
NCBI Protein Information:	conserved oligomeric Golgi complex subunit 2; COG complex subunit 2; conserved oligomeric Golgi complex protein 2; brefeldin A-sensitive, peripheral Golgi protein; low density lipoprotein receptor defect C complementing; low density lipoprotein receptor defect C-complementing protein
UniProt Protein Name:	Conserved oligomeric Golgi complex subunit 2
UniProt Synonym Protein Names:	Component of oligomeric Golgi complex 2; Low density lipoprotein receptor defect C-complementing protein
Protein Family:	Conserved oligomeric Golgi complex
UniProt Gene Name:	COG2
UniProt Entry Name:	COG2_HUMAN

	Western blot analysis of extracts of various cell lines, using COG2 antibody (CAB6251) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 80s.
	Immunohistochemistry of paraffin-embedded rat brain using COG2 antibody (CAB6251) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse kidney using COG2 antibody (CAB6251) at dilution of 1:100 (40x lens).
	Immunofluorescence analysis of U-2 OS cells using COG2 Polyclonal Antibody (CAB6251) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

Antibodies

Anti-COG2 Antibody (CAB12626)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)