Anti-CNTNAP1 Antibody (CAB10058)
- SKU:
- CAB10058
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-CNTNAP1 Antibody |
抗体コード: | CAB10058 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human CNTNAP1 (NP_003623.1). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | U-937, PC-12, Mouse brain, Rat kidney |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human CNTNAP1 (NP_003623.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | WGYY GCDE ELVG PLYA RSLG ASSY YSLL TAPR FARL HGIS GWSP RIGD PNPW LQID LMKK HRIR AVAT QGSF NSWD WVTR YMLL YGDR VDSW TPFY QRGH NSTF FGNV NESA VVRH DLHF HFTA RYIR IVPL AWNP RGKI GLRL GLYG CPYK ADIL YFDG DDAI SYRF PRGV SRSL WDVF AFSF KTEE KDGL LLHA EGAQ GDYV TLEL EGAH LLLH MSLG SSPI QPRP GHTT VSAG GVLN DQHW HYVR VDRF GRDV NFTL DGYV QRFI LNGD FERL NLDT E |
遺伝子ID: | 8506 |
Uniprot: | P78357 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 156kDa |
観察された分子量: | 170kDa |
同義語: | CNTNAP1, CASPR, CNTNAP, NRXN4, P190 |
バックグラウンド: | The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1, 384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein, ' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. |
UniProt Protein Function: | Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. |
NCBI Summary: | The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009] |
UniProt Code: | P78357 |
NCBI GenInfo Identifier: | 4505463 |
NCBI Gene ID: | 8506 |
NCBI Accession: | NP_003623.1 |
UniProt Related Accession: | P78357 |
Molecular Weight: | 152 |
NCBI Full Name: | contactin-associated protein 1 |
NCBI Synonym Full Names: | contactin associated protein 1 |
NCBI Official Symbol: | CNTNAP1 |
NCBI Official Synonym Symbols: | P190; CASPR; NRXN4; CNTNAP |
NCBI Protein Information: | contactin-associated protein 1 |
UniProt Protein Name: | Contactin-associated protein 1 |
UniProt Synonym Protein Names: | Neurexin IV; Neurexin-4; p190 |
UniProt Gene Name: | CNTNAP1 |
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