Anti-CNTFR Antibody (CAB12424)
- SKU:
- CAB12424
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CNTFR Antibody |
| 抗体コード: | CAB12424 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-342 of human CNTFR (NP_671693.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | SH-SY5Y |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-342 of human CNTFR (NP_671693.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FHRD SWHL RHQV LLHV GLPP REPV LSCR SNTY PKGF YCSW HLPT PTYI PNTF NVTV LHGS KIMV CEKD PALK NRCH IRYM HLFS TIKY KVSI SVSN ALGH NATA ITFD EFTI VKPD PPEN VVAR PVPS NPRR LEVT WQTP STWP DPES FPLK FFLR YRPL ILDQ WQHV ELSD GTAH TITD AYAG KEYI IQVA AKDN EIGT WSDW SVAA HATP WTEE PRHL TTEA QAAE TTTS TTSS LAPP PTTK ICDP GELG S |
| 遺伝子ID: | 1271 |
| Uniprot: | P26992 |
| セルラーロケーション: | Cell membrane, GPI-anchor, Lipid-anchor |
| 計算された分子量: | 40kDa |
| 観察された分子量: | 41kDa |
| 同義語: | CNTFR |
| バックグラウンド: | This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. |
| UniProt Protein Function: | CNTFR: Binds to CNTF. The alpha subunit provides the receptor specificity. Belongs to the type I cytokine receptor family. Type 3 subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, GPI anchor; Receptor, misc. Chromosomal Location of Human Ortholog: 9p13 Cellular Component: extrinsic to membrane Molecular Function:cytokine binding; ciliary neurotrophic factor receptor activity; receptor binding Biological Process: nervous system development; suckling behavior; positive regulation of cell proliferation; negative regulation of neuron apoptosis; signal transduction; sex differentiation |
| NCBI Summary: | This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011] |
| UniProt Code: | P26992 |
| NCBI GenInfo Identifier: | 1352099 |
| NCBI Gene ID: | 1271 |
| NCBI Accession: | P26992.2 |
| UniProt Related Accession: | P26992 |
| Molecular Weight: | 40kDa |
| NCBI Full Name: | Ciliary neurotrophic factor receptor subunit alpha |
| NCBI Synonym Full Names: | ciliary neurotrophic factor receptor |
| NCBI Official Symbol: | CNTFR |
| NCBI Protein Information: | ciliary neurotrophic factor receptor subunit alpha |
| UniProt Protein Name: | Ciliary neurotrophic factor receptor subunit alpha |
| Protein Family: | Ciliary neurotrophic factor receptor |
| UniProt Gene Name: | CNTFR |
| UniProt Entry Name: | CNTFR_HUMAN |
 | Western blot analysis of extracts of SH-SY5Y cells, using CNTFR antibody (CAB12424) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s. |
 | Immunohistochemistry of paraffin-embedded rat brain using CNTFR antibody (CAB12424) (40x lens). |
View AllClose