Anti-CMKLR1 Antibody (CAB15237)
- SKU:
- CAB15237
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CMKLR1 Antibody |
| 抗体コード: | CAB15237 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CMKLR1 (NP_001135815.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | LO2, Mouse brain |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 250-350 of human CMKLR1 (NP_001135815.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NRLA KTKK PFKI IVTI IITF FLCW CPYH TLNL LELH HTAM PGSV FSLG LPLA TALA IANS CMNP ILYV FMGQ DFKK FKVA LFSR LVNA LSED TGHS SYPS H |
| 遺伝子ID: | 1240 |
| Uniprot: | Q99788 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 42kDa |
| 観察された分子量: | 45kDa |
| 同義語: | CMKLR1, CHEMERINR, ChemR23, DEZ, RVER1 |
| バックグラウンド: |
| UniProt Protein Function: | CMKLR1: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1 Chromosomal Location of Human Ortholog: 12q24.1 Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane Molecular Function:G-protein coupled receptor activity; protein binding; chemokine receptor activity; receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of interleukin-12 production; inhibition of NF-kappaB transcription factor; regulation of calcium-mediated signaling; positive regulation of fat cell differentiation; immune response; chemotaxis; skeletal development |
| UniProt Code: | Q99788 |
| NCBI GenInfo Identifier: | 17380487 |
| NCBI Gene ID: | 1240 |
| NCBI Accession: | Q99788.2 |
| UniProt Secondary Accession: | Q99788,O75748, Q3KP37, Q5U0H0, Q99789, A8K6Y5, |
| UniProt Related Accession: | Q99788 |
| Molecular Weight: | 42,035 Da |
| NCBI Full Name: | Chemokine-like receptor 1 |
| NCBI Synonym Full Names: | chemokine-like receptor 1 |
| NCBI Official Symbol: | CMKLR1 |
| NCBI Official Synonym Symbols: | DEZ; RVER1; ChemR23; CHEMERINR |
| NCBI Protein Information: | chemokine-like receptor 1; chemerin receptor; resolvin E1 receptor; chemokine receptor-like 1; G-protein coupled receptor DEZ; G-protein coupled receptor ChemR23; orphan G-protein coupled receptor, Dez |
| UniProt Protein Name: | Chemokine-like receptor 1 |
| UniProt Synonym Protein Names: | G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ |
| UniProt Gene Name: | CMKLR1 |
| UniProt Entry Name: | CML1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CMKLR1 antibody (CAB15237) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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