Anti-CLNS1A Antibody (CAB16040)
- SKU:
- CAB16040
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CLNS1A Antibody |
| 抗体コード: | CAB16040 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human CLNS1A (NP_001284.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HT-29, 293T, DU145, Jurkat, HeLa, Mouse brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human CLNS1A (NP_001284.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MSFL KSFP PPGP AEGL LRQQ PDTE AVLN GKGL GTGT LYIA ESRL SWLD GSGL GFSL EYPT ISLH ALSR DRSD CLGE HLYV MVNA KFEE ESKE PVAD EEEE DSDD DVEP ITEF RFVP SDKS ALEA MFTA MCEC QALH PDPE DEDS DDYD GEEY DVEA HEQG QGDI PTFY TYEE GLSH LTAE GQAT LERL EGML SQSV SSQY NMAG VRTE DSIR DYED GMEV DTTP TVAG QFED ADVD H |
| 遺伝子ID: | 1207 |
| Uniprot: | P54105 |
| セルラーロケーション: | Cytoplasm, Nucleus, cytoskeleton, cytosol |
| 計算された分子量: | 26kDa |
| 観察された分子量: | 38kDa |
| 同義語: | CLNS1A, CLCI, CLNS1B, ICln |
| バックグラウンド: | This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ICLN: The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. Belongs to the pICln (TC 1.A.47) family. |
| UniProt Protein Details: | Protein type:Channel, chloride Chromosomal Location of Human Ortholog: 11q13.5-q14 Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus Molecular Function:protein binding; protein heterodimerization activity Biological Process: spliceosomal snRNP biogenesis |
| NCBI Summary: | This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015] |
| UniProt Code: | P54105 |
| NCBI GenInfo Identifier: | 1708393 |
| NCBI Gene ID: | 1207 |
| NCBI Accession: | P54105.1 |
| UniProt Secondary Accession: | P54105,Q0VDK6, Q9NRD2, Q9NRD3, B2RCS9, |
| UniProt Related Accession: | P54105 |
| Molecular Weight: | 26,215 Da |
| NCBI Full Name: | Methylosome subunit pICln |
| NCBI Synonym Full Names: | chloride nucleotide-sensitive channel 1A |
| NCBI Official Symbol: | CLNS1A |
| NCBI Official Synonym Symbols: | CLCI; ICln; CLNS1B |
| NCBI Protein Information: | methylosome subunit pICln |
| UniProt Protein Name: | Methylosome subunit pICln |
| UniProt Synonym Protein Names: | Chloride channel, nucleotide sensitive 1A; Chloride conductance regulatory protein ICln; I(Cln); Chloride ion current inducer protein; ClCI; Reticulocyte pICln |
| UniProt Gene Name: | CLNS1A |
| UniProt Entry Name: | ICLN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLNS1A antibody (CAB16040) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using CLNS1A antibody (CAB16040) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophageal using CLNS1A antibody (CAB16040) at dilution of 1:100 (40x lens). |
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