Anti-CLEC4C Antibody (CAB13702)
- SKU:
- CAB13702
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-CLEC4C Antibody |
| 抗体コード: | CAB13702 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-213 of human CLEC4C (NP_569708.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | K-562, Mouse spleen |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-213 of human CLEC4C (NP_569708.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NFMY SKTV KRLS KLRE YQQY HPSL TCVM EGKD IEDW SCCP TPWT SFQS SCYF ISTG MQSW TKSQ KNCS VMGA DLVV INTR EEQD FIIQ NLKR NSSY FLGL SDPG GRRH WQWV DQTP YNEN VTFW HSGE PNNL DERC AIIN FRSS EEWG WNDI HCHV PQKS ICKM KKIY I |
| 遺伝子ID: | 170482 |
| Uniprot: | Q8WTT0 |
| セルラーロケーション: | Membrane, Single-pass type II membrane protein |
| 計算された分子量: | 21kDa/25kDa |
| 観察された分子量: | 38kDa |
| 同義語: | CLEC4C, BDCA2, CD303, CLECSF11, CLECSF7, DLEC, HECL, PRO34150 |
| バックグラウンド: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. |
| UniProt Protein Function: | NRTN: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Belongs to the TGF-beta family. GDNF subfamily. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19p13.3 Cellular Component: axon; extracellular region Molecular Function:growth factor activity; receptor binding Biological Process: nervous system development; axon guidance; MAPKKK cascade; nerve development; neural crest cell migration; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway Disease: Hirschsprung Disease, Susceptibility To, 1 |
| NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8WTT0 |
| NCBI GenInfo Identifier: | 18466806 |
| NCBI Gene ID: | 170482 |
| NCBI Accession: | NP_569708 |
| UniProt Related Accession: | Q8WTT0 |
| Molecular Weight: | |
| NCBI Full Name: | C-type lectin domain family 4 member C isoform 1 |
| NCBI Synonym Full Names: | C-type lectin domain family 4 member C |
| NCBI Official Symbol: | CLEC4C |
| NCBI Official Synonym Symbols: | DLEC; HECL; BDCA2; CD303; BDCA-2; CLECSF7; CLECSF11; PRO34150 |
| NCBI Protein Information: | C-type lectin domain family 4 member C |
| UniProt Protein Name: | Neurturin |
| Protein Family: | Neurturin |
| UniProt Gene Name: | NRTN |
| UniProt Entry Name: | NRTN_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLEC4C antibody (CAB13702) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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