Anti-CLEC1B Antibody (CAB9971)
- SKU:
- CAB9971
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-CLEC1B Antibody |
| 抗体コード: | CAB9971 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human CLEC1B (NP_001092901.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HepG2, HL-60, Mouse thymus, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human CLEC1B (NP_001092901.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AVMQ RNYL QGEN ENRT GTLQ QLAK RFCQ YVVK QSEL KGTF KGHK CSPC DTNW RYYG DSCY GFFR HNLT WEES KQYC TDMN ATLL KIDN RNIV EYIK ARTH LIRW VGLS RQKS NEVW KWED GSVI SENM FEFL EDGK GNMN CAYF HNGK MHPT FCEN KHYL MCER KAGM TKVD QLP |
| 遺伝子ID: | 51266 |
| Uniprot: | Q9P126 |
| セルラーロケーション: | Membrane, Single-pass type II membrane protein |
| 計算された分子量: | 23kDa/26kDa |
| 観察された分子量: | 27kDa |
| 同義語: | CLEC1B, 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721 |
| バックグラウンド: |
| UniProt Protein Function: | CLEC1B: Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Receptor, misc.; Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.2 Cellular Component: integral to plasma membrane Molecular Function:protein binding; transmembrane receptor activity; carbohydrate binding Biological Process: cell surface receptor linked signal transduction; defense response; platelet formation |
| NCBI Summary: | Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | Q9P126 |
| NCBI GenInfo Identifier: | 134035066 |
| NCBI Gene ID: | 51266 |
| NCBI Accession: | Q9P126.2 |
| UniProt Secondary Accession: | Q9P126,Q6UWX7, Q8NHR6, |
| UniProt Related Accession: | Q9P126 |
| Molecular Weight: | 23,096 Da |
| NCBI Full Name: | C-type lectin domain family 1 member B |
| NCBI Synonym Full Names: | C-type lectin domain family 1, member B |
| NCBI Official Symbol: | CLEC1B |
| NCBI Official Synonym Symbols: | CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik |
| NCBI Protein Information: | C-type lectin domain family 1 member B; CLEC-2; C-type lectin-like receptor 2; C-type lectin-like receptor-2 |
| UniProt Protein Name: | C-type lectin domain family 1 member B |
| UniProt Synonym Protein Names: | C-type lectin-like receptor 2; CLEC-2 |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC1B |
| UniProt Entry Name: | CLC1B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLEC1B antibody (CAB9971) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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