| バックグラウンド: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. |
| UniProt Protein Function: | CLEC12A: Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.31 |
| NCBI Summary: | This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011] |
| UniProt Code: | Q5QGZ9 |
| NCBI GenInfo Identifier: | 308153619 |
| NCBI Gene ID: | 160364 |
| NCBI Accession: | Q5QGZ9.3 |
| UniProt Secondary Accession: | Q5QGZ9,Q6P4H1, Q6RH77, Q6RH78, Q8TDQ6, B2RA16, |
| UniProt Related Accession: | Q5QGZ9 |
| Molecular Weight: | |
| NCBI Full Name: | C-type lectin domain family 12 member A |
| NCBI Synonym Full Names: | C-type lectin domain family 12 member A |
| NCBI Official Symbol: | CLEC12A |
| NCBI Official Synonym Symbols: | CLL1; MICL; CD371; CLL-1; DCAL-2 |
| NCBI Protein Information: | C-type lectin domain family 12 member A |
| UniProt Protein Name: | C-type lectin domain family 12 member A |
| UniProt Synonym Protein Names: | C-type lectin-like molecule 1; CLL-1; Dendritic cell-associated lectin 2; DCAL-2; Myeloid inhibitory C-type lectin-like receptor; MICL |
| Protein Family: | C-type lectin domain family |
| UniProt Gene Name: | CLEC12A |
