Anti-CLDN7 Antibody (CAB2035)
- SKU:
- CAB2035
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CLDN7 Antibody |
| 抗体コード: | CAB2035 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-211 of human CLDN7 (NP_001298.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | MCF7, HT-29, A-549, HO-8910PM, Mouse lung, Mouse kidney, Mouse liver, rat kidney, rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-211 of human CLDN7 (NP_001298.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | QWQM SSYA GDNI ITAQ AMYK GLWM DCVT QSTG MMSC KMYD SVLA LSAA LQAT RALM VVSL VLGF LAMF VATM GMKC TRCG GDDK VKKA RIAM GGGI IFIV AGLA ALVA CSWY GHQI VTDF YNPL IPTN IKYE FGPA IFIG WAGS ALVI LGGA LLSC SCPG NESK AGYR VPRS YPKS NSSK EYV |
| 遺伝子ID: | 1366 |
| Uniprot: | O95471 |
| セルラーロケーション: | Cell junction, Cell membrane, Lateral cell membrane, Multi-pass membrane protein, tight junction |
| 計算された分子量: | 16kDa/22kDa |
| 観察された分子量: | 29kDa |
| 同義語: | CLDN7, CEPTRL2, CLDN-7, CPETRL2, Hs.84359, claudin-1, claudin-7 |
| バックグラウンド: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found. |
| UniProt Protein Function: | Claudin-7: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: apicolateral plasma membrane; basolateral plasma membrane; integral to membrane; lateral plasma membrane; tight junction Molecular Function:cell adhesion molecule binding; identical protein binding; protein binding; structural molecule activity Biological Process: calcium-independent cell-cell adhesion; negative regulation of apoptosis; negative regulation of cell adhesion; negative regulation of protein homooligomerization; positive regulation of cell proliferation; positive regulation of defense response to virus by host |
| NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010] |
| UniProt Code: | O95471 |
| NCBI GenInfo Identifier: | 311033475 |
| NCBI Gene ID: | 1366 |
| NCBI Accession: | O95471.4 |
| UniProt Secondary Accession: | O95471,Q6IPN3, Q7Z4Y7, Q9BVN0, B2R9X7, D3DTP0, |
| UniProt Related Accession: | O95471 |
| Molecular Weight: | 16,837 Da |
| NCBI Full Name: | Claudin-7 |
| NCBI Synonym Full Names: | claudin 7 |
| NCBI Official Symbol: | CLDN7 |
| NCBI Official Synonym Symbols: | CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1 |
| NCBI Protein Information: | claudin-7 |
| UniProt Protein Name: | Claudin-7 |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN7 |
| UniProt Entry Name: | CLD7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLDN7 antibody (CAB2035) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
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