Anti-CLDN5 Antibody (CAB10207)
- SKU:
- CAB10207
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CLDN5 Antibody |
| 抗体コード: | CAB10207 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-303 of human CLDN5 (NP_001124333.1). |
| 申し込み: | IF |
| 推奨希釈: | IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-303 of human CLDN5 (NP_001124333.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | REFY DPSV PVSQ KYEL GAAL YIGW AATA LLMV GGCL LCCG AWVC TGRP DLSF PVKY SAPR RPTA TGDY DKKN YV |
| 遺伝子ID: | 7122 |
| Uniprot: | O00501 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
| 計算された分子量: | 23kDa |
| 観察された分子量: | 27kDa |
| 同義語: | CLDN5, AWAL, BEC1, CPETRL1, TMVCF, claudin-5 |
| バックグラウンド: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | Claudin-5: Plays a major role in tight junction-specific obliteration of the intercellular space. Belongs to the claudin family. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: apicolateral plasma membrane; cortical actin cytoskeleton; integral to membrane; intercellular junction; plasma membrane; tight junction Molecular Function:identical protein binding Biological Process: calcium-independent cell-cell adhesion; intercellular junction assembly; learning; palate development; transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008] |
| UniProt Code: | O00501 |
| NCBI GenInfo Identifier: | 6685271 |
| NCBI Gene ID: | 7122 |
| NCBI Accession: | O00501.1 |
| UniProt Secondary Accession: | O00501,Q53XW2, Q8WUW3, B3KS11, |
| UniProt Related Accession: | O00501 |
| Molecular Weight: | 23kDa |
| NCBI Full Name: | Claudin-5 |
| NCBI Synonym Full Names: | claudin 5 |
| NCBI Official Symbol: | CLDN5 |
| NCBI Official Synonym Symbols: | AWAL; BEC1; TMVCF; CPETRL1 |
| NCBI Protein Information: | claudin-5 |
| UniProt Protein Name: | Claudin-5 |
| UniProt Synonym Protein Names: | Transmembrane protein deleted in VCFS; TMDVCF |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN5 |
 | Immunofluorescence analysis of NIH/3T3 cells using CLDN5 antibody (CAB10207) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of U2OS cells using CLDN5 antibody (CAB10207) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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