Anti-CLDN3 Antibody (CAB2946)
- SKU:
- CAB2946
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CLDN3 Antibody |
| 抗体コード: | CAB2946 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human CLDN3 |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:100 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HT-29, Mouse intestine |
| 免疫原: | Recombinant protein of human CLDN3 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 1365 |
| Uniprot: | O15551 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
| 計算された分子量: | 23kDa |
| 観察された分子量: | 23kDa |
| 同義語: | CLDN3, C7orf1, CPE-R2, CPETR2, HRVP1, RVP1, claudin-3 |
| バックグラウンド: | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. |
| UniProt Protein Function: | Claudin-3: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. CLDN3 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the claudin family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Cytoskeletal Chromosomal Location of Human Ortholog: 7q11.23 Cellular Component: apicolateral plasma membrane; integral to membrane; integral to plasma membrane; lateral plasma membrane; tight junction Molecular Function:identical protein binding; structural molecule activity; transmembrane receptor activity Biological Process: calcium-independent cell-cell adhesion; protein heterooligomerization; protein homooligomerization; response to hypoxia; signal transduction |
| NCBI Summary: | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intronless gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares aa sequence similarity with a putative apoptosis-related protein found in rat. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O15551 |
| NCBI GenInfo Identifier: | 6685273 |
| NCBI Gene ID: | 1365 |
| NCBI Accession: | O15551.1 |
| UniProt Secondary Accession: | O15551,Q9Z0G9, Q63400, |
| UniProt Related Accession: | O15551 |
| Molecular Weight: | 23,319 Da |
| NCBI Full Name: | Claudin-3 |
| NCBI Synonym Full Names: | claudin 3 |
| NCBI Official Symbol: | CLDN3 |
| NCBI Official Synonym Symbols: | RVP1; HRVP1; C7orf1; CPE-R2; CPETR2 |
| NCBI Protein Information: | claudin-3 |
| UniProt Protein Name: | Claudin-3 |
| UniProt Synonym Protein Names: | Clostridium perfringens enterotoxin receptor 2; CPE-R 2; CPE-receptor 2; Rat ventral prostate.1 protein homolog; hRVP1 |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN3 |
| UniProt Entry Name: | CLD3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLDN3 antibody (CAB2946) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunohistochemistry of paraffin-embedded mouse stomach using CLDN3 antibody (CAB2946) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using CLDN3 antibody (CAB2946) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using CLDN3 antibody (CAB2946) (40x lens). |
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