Anti-CLDN14 Antibody (CAB7787)
- SKU:
- CAB7787
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CLDN14 Antibody |
| 抗体コード: | CAB7787 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-85 of human CLDN14 (NP_652763.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | 293T, LO2, A-431, U-87MG |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-85 of human CLDN14 (NP_652763.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TILP HWRR TAHV GTNI LTAV SYLK GLWM ECVW HSTG IYQC QIYR SLLA LPQD LQAA RALM V |
| 遺伝子ID: | 23562 |
| Uniprot: | O95500 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, tight junction |
| 計算された分子量: | 25kDa |
| 観察された分子量: | 24kDa |
| 同義語: | CLDN14, DFNB29 |
| バックグラウンド: | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. |
| UniProt Protein Function: | Claudin-14: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Defects in CLDN14 are the cause of deafness autosomal recessive type 29 (DFNB29). DFNB29 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Belongs to the claudin family. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 21q22.3 Cellular Component: tight junction; endoplasmic reticulum; plasma membrane; integral to membrane Molecular Function:identical protein binding; structural molecule activity Biological Process: intercellular junction assembly and maintenance; protein complex assembly; calcium-independent cell-cell adhesion Disease: Deafness, Autosomal Recessive 29 |
| NCBI Summary: | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010] |
| UniProt Code: | O95500 |
| NCBI GenInfo Identifier: | 6685304 |
| NCBI Gene ID: | 23562 |
| NCBI Accession: | O95500.1 |
| UniProt Related Accession: | O95500 |
| Molecular Weight: | 239 |
| NCBI Full Name: | Claudin-14 |
| NCBI Synonym Full Names: | claudin 14 |
| NCBI Official Symbol: | CLDN14 |
| NCBI Official Synonym Symbols: | DFNB29 |
| NCBI Protein Information: | claudin-14 |
| UniProt Protein Name: | Claudin-14 |
| Protein Family: | Claudin |
| UniProt Gene Name: | CLDN14 |
| UniProt Entry Name: | CLD14_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLDN14 antibody (CAB7787) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
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