Anti-CLCN6 Antibody (CAB17458)
- SKU:
- CAB17458
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Description
| 抗体名: | Anti-CLCN6 Antibody |
| 抗体コード: | CAB17458 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | IHC |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CLCN6 (NP_001277.1). |
| 申し込み: | IHC |
| 推奨希釈: | IHC 1:50 - 1:100 |
| 反応性: | Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human CLCN6 (NP_001277.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAGC RGSL CCCC RWCC CCGE RETR TPEE LTIL GETQ EEED EILP RKDY ESLD YDRC INDP YLEV LETM DNKK GRRY EAVK |
| 遺伝子ID: | 1185 |
| Uniprot: | P51797 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
 | Immunohistochemistry - CLCN6 Polyclonal Antibody (CAB17458) |
| 同義語: | CLC-6, CLCN6 |
| バックグラウンド: | This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012] |
| UniProt Protein Function: | Function: Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter. |
| UniProt Protein Details: | Subcellular location: Endosome membrane; Multi-pass membrane protein. Note: Detected in detergent-resistant lipid rafts. Ref.11 Tissue specificity: Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform 3 is only detected in kidney. Ref.1 Ref.2 Ref.10 Post-translational modification: N-glycosylated on several asparagine residues. Ref.11 Miscellaneous: The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters By similarity. Sequence similarities: Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily. [View classification]Contains 2 CBS domains. |
| NCBI Summary: | This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P51797 |
| NCBI GenInfo Identifier: | 4502873 |
| NCBI Gene ID: | 1185 |
| NCBI Accession: | NP_001277 |
| UniProt Related Accession: | P51797 |
| Molecular Weight: | 93kDa |
| NCBI Full Name: | chloride transport protein 6 isoform 1 |
| NCBI Synonym Full Names: | chloride voltage-gated channel 6 |
| NCBI Official Symbol: | CLCN6 |
| NCBI Official Synonym Symbols: | CLC-6 |
| NCBI Protein Information: | chloride transport protein 6 |
| UniProt Protein Name: | Chloride transport protein 6 |
| UniProt Synonym Protein Names: | Chloride channel protein 6 |
| Protein Family: | Chloride transport protein |
| UniProt Gene Name: | CLCN6 |
| UniProt Entry Name: | CLCN6_HUMAN |