Anti-CLCN2 Antibody (CAB6120)
- SKU:
- CAB6120
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-CLCN2 Antibody |
| 抗体コード: | CAB6120 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human CLCN2 (NP_004357.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse brain, Mouse testis |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human CLCN2 (NP_004357.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RTSL HKTH TIFS LLGV DHAY VTSI GRLI GIVT LKEL RKAI EGSV TAQG VKVR PPLA SFRD SATS SSDT ETTE VHAL WGPH SRHG LPRE GSPS DSDD KCQ |
| 遺伝子ID: | 1181 |
| Uniprot: | P51788 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 14kDa/93kDa/95kDa/96kDa/98kDa |
| 観察された分子量: | 90-98kDa |
| 同義語: | CLCN2, CIC-2, CLC2, ECA2, ECA3, EGI11, EGI3, EGMA, EJM6, EJM8, LKPAT, clC-2 |
| バックグラウンド: | This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CLCN2: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. Defects in CLCN2 are associated with susceptibility to epilepsy, idiopathic generalized type 11 (EIG11). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CLCN2 are associated with juvenile absence epilepsy type 2 (JAE2). JAE is a subtype of idiopathic generalized epilepsy (IGE) characterized by onset occurring around puberty, absence seizures, generalized tonic- clonic seizures (GTCS), GTCS on awakening and myoclonic seizures. Defects in CLCN2 are associated with juvenile myoclonic epilepsy type 8 (EJM8). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter; Transporter, ion channel; Channel, chloride; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3q27.1 Cellular Component: plasma membrane Molecular Function:voltage-gated chloride channel activity Biological Process: transport Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 11; Leukoencephalopathy With Ataxia |
| NCBI Summary: | This gene encodes a voltage-gated chloride channel. The encoded protein is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012] |
| UniProt Code: | P51788 |
| NCBI GenInfo Identifier: | 288558807 |
| NCBI Gene ID: | 1181 |
| NCBI Accession: | P51788.2 |
| UniProt Secondary Accession: | P51788,O14864, Q6IPA9, Q8WU13, B4DQT9, B4DZ58, E9PBD9 E9PCD2, |
| UniProt Related Accession: | P51788 |
| Molecular Weight: | 95,399 Da |
| NCBI Full Name: | Chloride channel protein 2 |
| NCBI Synonym Full Names: | chloride voltage-gated channel 2 |
| NCBI Official Symbol: | CLCN2 |
| NCBI Official Synonym Symbols: | CLC2; ECA2; ECA3; EGI3; EGMA; EJM6; EJM8; CIC-2; EGI11; LKPAT; clC-2 |
| NCBI Protein Information: | chloride channel protein 2 |
| UniProt Protein Name: | Chloride channel protein 2 |
| Protein Family: | Chloride channel protein |
| UniProt Gene Name: | CLCN2 |
| UniProt Entry Name: | CLCN2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CLCN2 Antibody (CAB6120) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |