Anti-CLCA2 Antibody (CAB17056)
- SKU:
- CAB17056
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-CLCA2 Antibody |
| 抗体コード: | CAB17056 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-160 of human CLCA2 (NP_006527.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 32-160 of human CLCA2 (NP_006527.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | GVQL QDNG YNGL LIAI NPQV PENQ NLIS NIKE MITE ASFY LFNA TKRR VFFR NIKI LIPA TWKA NNNS KIKQ ESYE KANV IVTD WYGA HGDD PYTL QYRG CGKE GKYI HFTP NFLL NDNL TAGY GSRG R |
| 遺伝子ID: | 9635 |
| Uniprot: | Q9UQC9 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | CLCA2, CACC, CACC3, CLCRG2, CaCC-3 |
| バックグラウンド: | This gene encodes a member of the calcium-activated chloride channel regulator (CLCR) family of proteins. Members of this family regulate the transport of chloride across the plasma membrane. The encoded protein is autoproteolytically processed to generate N- and C- terminal fragments. Expression of this gene is upregulated by the tumor suppressor protein p53 in response to DNA damage. In breast cancer, expression of this gene is downregulated and the encoded protein may inhibit migration and invasion while promoting mesenchymal-to-epithelial transition in cancer cell lines. |
| UniProt Protein Function: | CLCA5: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. Belongs to the CLCR family. |
| UniProt Protein Details: | Protein type:Channel, chloride; Membrane protein, integral Chromosomal Location of Human Ortholog: 1p22.3 Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; basal plasma membrane; cell junction Molecular Function:chloride channel activity; metallopeptidase activity; metal ion binding; ligand-gated ion channel activity Biological Process: transport; proteolysis; cell adhesion; transmembrane transport |
| NCBI Summary: | The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Since this protein is expressed predominantly in trachea and lung, it is suggested to play a role in the complex pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization, and furthermore, it has been implicated to act as a tumor suppressor gene for breast cancer. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UQC9 |
| NCBI GenInfo Identifier: | 5729769 |
| NCBI Gene ID: | 9635 |
| NCBI Accession: | NP_006527.1 |
| UniProt Secondary Accession: | Q9UQC9,Q9Y6N2, A8K2T3, |
| UniProt Related Accession: | Q9UQC9 |
| Molecular Weight: | 103,941 Da |
| NCBI Full Name: | calcium-activated chloride channel regulator 2 |
| NCBI Synonym Full Names: | chloride channel accessory 2 |
| NCBI Official Symbol: | CLCA2 |
| NCBI Official Synonym Symbols: | CACC; CACC3; CLCRG2; CaCC-3 |
| NCBI Protein Information: | calcium-activated chloride channel regulator 2 |
| UniProt Protein Name: | Calcium-activated chloride channel regulator 2 |
| UniProt Synonym Protein Names: | Calcium-activated chloride channel family member 2; hCLCA2 |
| Protein Family: | Calcium-activated chloride channel regulator |
| UniProt Gene Name: | CLCA2 |
| UniProt Entry Name: | CLCA2_HUMAN |