Anti-CHTF18 Antibody (CAB17752)
- SKU:
- CAB17752
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
抗体名: | Anti-CHTF18 Antibody |
抗体コード: | CAB17752 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 794-975 of human CHTF18 (NP_071375.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Rat |
ポジティブサンプル: | HeLa |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 794-975 of human CHTF18 (NP_071375.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | GTML AYSL TYRQ ERTP DGQY IYRL EPNV EELC RFPE LPAR KPLT YQTK QLIA REIE VEKM RRAE ASAR VENS PQVD GSPP GLEG LLGG IGEK GVHR PAPR NHEQ RLEH IMRR AARE EQPE KDFF GRVV VRST AVPS AGDT APEQ DSVE RRMG TAVG RSEV WFRF NEGV SNAV RRSL YIRD LL |
遺伝子ID: | 63922 |
Uniprot: | Q8WVB6 |
セルラーロケーション: | |
計算された分子量: | |
観察された分子量: | 130kDa |
同義語: | C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL, CHTF18 |
バックグラウンド: | This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016] |
UniProt Protein Function: | CTF18: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single- stranded and primed DNAs and has weak ATPase activity that is stimulated by the presence of primed DNA, replication protein A (RPA) and by proliferating cell nuclear antigen (PCNA). The CTF18- RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates DNA polymerase POLH. Belongs to the activator 1 small subunits family. CTF18 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:DNA replication Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; membrane; nucleoplasm Molecular Function:DNA clamp loader activity; protein binding; single-stranded DNA-dependent ATPase activity |
NCBI Summary: | This gene encodes a protein which is a component of a replication factor C (RFC) complex, which loads proliferating cell nuclear antigen (PCNA) on to DNA during the S phase of cell cycle. The encoded protein may interact with other proteins, including RFC complex 3, to form a clamp loader complex that plays a role in sister chromatid cohesion during metaphase-anaphase transition. [provided by RefSeq, Jan 2016] |
UniProt Code: | Q8WVB6 |
NCBI GenInfo Identifier: | 74751544 |
NCBI Gene ID: | 63922 |
NCBI Accession: | Q8WVB6.1 |
UniProt Secondary Accession: | Q8WVB6,Q7Z6Y4, Q7Z6Y6, Q9BR83, Q9BRG5, Q9H7K3, B7ZBA2 D3DU68, |
UniProt Related Accession: | Q8WVB6 |
Molecular Weight: | 61,869 Da |
NCBI Full Name: | Chromosome transmission fidelity protein 18 homolog |
NCBI Synonym Full Names: | chromosome transmission fidelity factor 18 |
NCBI Official Symbol: | CHTF18 |
NCBI Official Synonym Symbols: | CHL12; Ctf18; RUVBL; C16orf41; C321D2.2; C321D2.3; C321D2.4 |
NCBI Protein Information: | chromosome transmission fidelity protein 18 homolog |
UniProt Protein Name: | Chromosome transmission fidelity protein 18 homolog |
UniProt Synonym Protein Names: | CHL12 |
Protein Family: | Chromosome transmission fidelity protein |
UniProt Gene Name: | CHTF18 |
UniProt Entry Name: | CTF18_HUMAN |