Anti-CHRNA9 Antibody (CAB9975)
- SKU:
- CAB9975
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CHRNA9 Antibody |
| 抗体コード: | CAB9975 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-240 of human CHRNA9 (NP_060051.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:4000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | B cells, HeLa, HT-1080, Jurkat, Mouse thymus, Rat brain, Rat thymus |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-240 of human CHRNA9 (NP_060051.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ADGK YAQK LFND LFED YSNA LRPV EDTD KVLN VTLQ ITLS QIKD MDER NQIL TAYL WIRQ IWHD AYLT WDRD QYDG LDSI RIPS DLVW RPDI VLYN KADD ESSE PVNT NVVL RYDG LITW DAPA ITKS SCVV DVTY FPFD NQQC NLTF GSWT YNGN QVDI FNAL DSGD LSDF IEDV EWEV HGMP AVKN VISY GCCS EPYP DVTF TLLL KRRS SFY |
| 遺伝子ID: | 55584 |
| Uniprot: | Q9UGM1 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| 計算された分子量: | 54kDa |
| 観察された分子量: | 75kDa |
| 同義語: | CHRNA9, HSA243342, NACHRA9 |
| バックグラウンド: | This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. |
| UniProt Protein Function: | nAChRA9: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha- 9/CHRNA9 sub-subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, ligand-gated; Channel, cation Chromosomal Location of Human Ortholog: 4p14 Cellular Component: cell junction; cytosol; integral to plasma membrane; nicotinic acetylcholine-gated receptor-channel complex; plasma membrane; postsynaptic membrane Molecular Function:acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated cation channel activity; calcium channel activity; nicotinic acetylcholine-activated cation-selective channel activity Biological Process: detection of mechanical stimulus involved in sensory perception of sound; elevation of cytosolic calcium ion concentration; inner ear morphogenesis; synaptic transmission; synaptic transmission, cholinergic |
| NCBI Summary: | This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012] |
| UniProt Code: | Q9UGM1 |
| NCBI GenInfo Identifier: | 308153406 |
| NCBI Gene ID: | 55584 |
| NCBI Accession: | Q9UGM1.2 |
| UniProt Secondary Accession: | Q9UGM1,Q14CY7, Q4W5A2, Q9NYV2, |
| UniProt Related Accession: | Q9UGM1 |
| Molecular Weight: | 54,807 Da |
| NCBI Full Name: | Neuronal acetylcholine receptor subunit alpha-9 |
| NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 9 subunit |
| NCBI Official Symbol: | CHRNA9 |
| NCBI Official Synonym Symbols: | NACHRA9; HSA243342 |
| NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-9 |
| UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-9 |
| UniProt Synonym Protein Names: | Nicotinic acetylcholine receptor subunit alpha-9; NACHR alpha-9 |
| Protein Family: | Neuronal acetylcholine receptor |
| UniProt Gene Name: | CHRNA9 |
| UniProt Entry Name: | ACHA9_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CHRNA9 antibody (CAB9975) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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