Anti-CHRNA6 Antibody (CAB14081)
- SKU:
- CAB14081
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-CHRNA6 Antibody |
| 抗体コード: | CAB14081 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-440 of human CHRNA6 (NP_004189.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | Raji, Rat liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-440 of human CHRNA6 (NP_004189.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PQVL LMRW PLDK TRGT GSDA VPRG LARR PAKG KLAS HGEP RHLK ECFH CHKS NELA TSKR RLSH QPLQ WVVE NSEH SPEV EDVI NSVQ FIA |
| 遺伝子ID: | 8973 |
| Uniprot: | Q15825 |
| セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
| 計算された分子量: | 55kDa/56kDa |
| 観察された分子量: | 57kDa |
| 同義語: | CHRNA6, CHNRA6 |
| バックグラウンド: | This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. |
| UniProt Protein Function: | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. |
| NCBI Summary: | This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010] |
| UniProt Code: | Q15825 |
| NCBI GenInfo Identifier: | 313482792 |
| NCBI Gene ID: | 8973 |
| NCBI Accession: | NP_001186208.1 |
| UniProt Secondary Accession: | Q15825,B2R8V4, B4DQH1, |
| UniProt Related Accession: | Q15825 |
| Molecular Weight: | 54 |
| NCBI Full Name: | neuronal acetylcholine receptor subunit alpha-6 isoform 2 |
| NCBI Synonym Full Names: | cholinergic receptor nicotinic alpha 6 subunit |
| NCBI Official Symbol: | CHRNA6 |
| NCBI Official Synonym Symbols: | CHNRA6 |
| NCBI Protein Information: | neuronal acetylcholine receptor subunit alpha-6 |
| UniProt Protein Name: | Neuronal acetylcholine receptor subunit alpha-6 |
| UniProt Gene Name: | CHRNA6 |
 | Western blot analysis of extracts of various cell lines, using CHRNA6 antibody (CAB14081) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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