Anti-CHRM4 Antibody (CAB2866)
- SKU:
- CAB2866
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-CHRM4 Antibody |
抗体コード: | CAB2866 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthetic peptide of human CHRM4 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | NIH/3T3 |
免疫原: | A synthetic peptide of human CHRM4 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 1132 |
Uniprot: | P08173 |
セルラーロケーション: | Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse |
計算された分子量: | 53kDa |
観察された分子量: | 53kDa |
同義語: | CHRM4, HM4, M4R |
バックグラウンド: | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. |
UniProt Protein Function: | mAChR M4: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM4 sub-subfamily. |
UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1 Chromosomal Location of Human Ortholog: 11p12-p11.2 Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction Molecular Function:G-protein coupled acetylcholine receptor activity Biological Process: regulation of locomotion; cell proliferation; acetylcholine receptor signaling, muscarinic pathway; cell surface receptor linked signal transduction; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; signal transduction |
NCBI Summary: | The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008] |
UniProt Code: | P08173 |
NCBI GenInfo Identifier: | 23503039 |
NCBI Gene ID: | 1132 |
NCBI Accession: | P08173.2 |
UniProt Secondary Accession: | P08173,Q0VD60, Q4VBK7, B2RPP4, |
UniProt Related Accession: | P08173 |
Molecular Weight: | 479 |
NCBI Full Name: | Muscarinic acetylcholine receptor M4 |
NCBI Synonym Full Names: | cholinergic receptor, muscarinic 4 |
NCBI Official Symbol: | CHRM4 |
NCBI Official Synonym Symbols: | HM4; M4R |
NCBI Protein Information: | muscarinic acetylcholine receptor M4; acetylcholine receptor, muscarinic 4 |
UniProt Protein Name: | Muscarinic acetylcholine receptor M4 |
Protein Family: | Muscarinic acetylcholine receptor |
UniProt Gene Name: | CHRM4 |
UniProt Entry Name: | ACM4_HUMAN |
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