Anti-CHL1 Antibody (CAB9681)
- SKU:
- CAB9681
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CHL1 Antibody |
| 抗体コード: | CAB9681 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 690-950 of human CHL1 (NP_001240316.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-251MG, NCI-H460, Jurkat, Mouse brain, Rat spinal cord, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 690-950 of human CHL1 (NP_001240316.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | NEVG RSQP SQPS DHHE TPPA APDR NPQN IRVQ ASQP KEMI IKWE PLKS MEQN GPGL EYRV TWKP QGAP VEWE EETV TNHT LRVM TPAV YAPY DVKV QAIN QLGS GPDP QSVT LYSG EDYP DTAP VIHG VDVI NSTL VKVT WSTV PKDR VHGR LKGY QINW WKTK SLLD GRTH PKEV NILR FSGQ RNSG MVPS LDAF SEFH LTVL AYNS KGAG PESE PYIF QTPE GVPE QPTF LKVI KVDK DTAT LSWG LPKK LNGN LTGY L |
| 遺伝子ID: | 10752 |
| Uniprot: | O00533 |
| セルラーロケーション: | Cell membrane, Secreted, Single-pass type I membrane protein, extracellular matrix, extracellular space |
| 計算された分子量: | 135kDa/136kDa |
| 観察された分子量: | 135kDa |
| 同義語: | CHL1, CALL, L1CAM2 |
| バックグラウンド: | The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. |
| UniProt Protein Function: | CHL1: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Cell development/differentiation; Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 3p26.3 Cellular Component: apical part of cell; dendrite; integral component of membrane; plasma membrane; proteinaceous extracellular matrix Molecular Function:protease binding Biological Process: adult locomotory behavior; axon guidance; axon regeneration; cell adhesion; cognition; negative regulation of neuron apoptosis; neuron migration; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a member of the L1 gene family of neural cell adhesion molecules. It is a neural recognition molecule that may be involved in signal transduction pathways. The deletion of one copy of this gene may be responsible for mental defects in patients with 3p- syndrome. This protein may also play a role in the growth of certain cancers. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Nov 2011] |
| UniProt Code: | O00533 |
| NCBI GenInfo Identifier: | 358438179 |
| NCBI Gene ID: | 10752 |
| NCBI Accession: | NP_001240316.1 |
| UniProt Secondary Accession: | O00533,Q2M3G2, Q59FY0, B7ZL03, |
| UniProt Related Accession: | O00533 |
| Molecular Weight: | |
| NCBI Full Name: | neural cell adhesion molecule L1-like protein isoform 2 |
| NCBI Synonym Full Names: | cell adhesion molecule L1 like |
| NCBI Official Symbol: | CHL1 |
| NCBI Official Synonym Symbols: | CALL; L1CAM2 |
| NCBI Protein Information: | neural cell adhesion molecule L1-like protein |
| UniProt Protein Name: | Neural cell adhesion molecule L1-like protein |
| UniProt Synonym Protein Names: | Close homolog of L1 |
| Protein Family: | ATP-dependent DNA helicase |
| UniProt Gene Name: | CHL1 |
 | Western blot analysis of extracts of various cell lines, using CHL1 antibody (CAB9681) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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