Anti-CHD2 Antibody (CAB13478)
- SKU:
- CAB13478
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Frequently bought together:
Description
| 抗体名: | Anti-CHD2 Antibody |
| 抗体コード: | CAB13478 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1700 to the C-terminus of human CHD2 (NP_001262.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | A-431, Jurkat, HeLa, LO2, K-562 |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1700 to the C-terminus of human CHD2 (NP_001262.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | YDQY SSDR DHRG HRDY YDRH HHDS KRRR SDEF RPQN YHQQ DFRR MSDH RPAM GYHG QGPS DHYR SFHT DKLG EYKQ PLPP LHPA VSDP RSPP SQKS PHDS KSPL DHRS PLER SLEQ KNNP DYNW NVRK T |
| 遺伝子ID: | 1106 |
| Uniprot: | O14647 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 56kDa/200kDa/211kDa |
| 観察された分子量: | 270kDa |
| 同義語: | CHD2, EEOC |
| バックグラウンド: | The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| UniProt Protein Function: | CHD-2: Sequence-selective DNA-binding protein. Belongs to the SNF2/RAD54 helicase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.6.4.12; Helicase; DNA-binding Chromosomal Location of Human Ortholog: 15q26 Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleolus; nucleus Molecular Function:ATP-dependent DNA helicase activity; DNA binding; histone binding; ATP binding Biological Process: regulation of transcription from RNA polymerase II promoter; muscle development; transcription, DNA-dependent; chromatin modification; response to DNA damage stimulus; DNA duplex unwinding Disease: Epileptic Encephalopathy, Childhood-onset |
| NCBI Summary: | The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14647 |
| NCBI GenInfo Identifier: | 119370320 |
| NCBI Gene ID: | 1106 |
| NCBI Accession: | O14647.2 |
| UniProt Secondary Accession: | O14647,Q96IP5, C6G482, |
| UniProt Related Accession: | O14647 |
| Molecular Weight: | 1828 |
| NCBI Full Name: | Chromodomain-helicase-DNA-binding protein 2 |
| NCBI Synonym Full Names: | chromodomain helicase DNA binding protein 2 |
| NCBI Official Symbol: | CHD2 |
| NCBI Official Synonym Symbols: | EEOC |
| NCBI Protein Information: | chromodomain-helicase-DNA-binding protein 2; CHD-2; ATP-dependent helicase CHD2 |
| UniProt Protein Name: | Chromodomain-helicase-DNA-binding protein 2 |
| UniProt Synonym Protein Names: | ATP-dependent helicase CHD2 |
| Protein Family: | Chromodomain-helicase-DNA-binding protein |
| UniProt Gene Name: | CHD2 |
| UniProt Entry Name: | CHD2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CHD2 antibody (CAB13478) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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