Anti-cGAS Antibody (CAB8335)
- SKU:
- CAB8335
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
抗体名: | Anti-cGAS Antibody |
抗体コード: | CAB8335 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF IP |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-522 of human cGAS (NP_612450.2). |
申し込み: | WB IHC IF IP |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:100 IP 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | THP-1, DU145, MCF7, U-251MG, HeLa, Mouse brain, Mouse heart, Rat heart |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-522 of human cGAS (NP_612450.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | KQLR LKPF YLVP KHAK EGNG FQEE TWRL SFSH IEKE ILNN HGKS KTCC ENKE EKCC RKDC LKLM KYLL EQLK ERFK DKKH LDKF SSYH VKTA FFHV CTQN PQDS QWDR KDLG LCFD NCVT YFLQ CLRT EKLE NYFI PEFN LFSS NLID KRSK EFLT KQIE YERN NEFP VFDE F |
遺伝子ID: | 115004 |
Uniprot: | Q8N884 |
セルラーロケーション: | Cytoplasm, cytosol |
計算された分子量: | 49kDa/58kDa |
観察された分子量: | 59kDa |
同義語: | MB21D1, C6orf150, cGAS, h-cGAS, CGAS |
バックグラウンド: |
UniProt Protein Function: | MB21D1: Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G(2',5')pA(3',5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. |
UniProt Protein Details: | Protein type:EC 2.7.7.86; Enzyme, cellular metabolism Chromosomal Location of Human Ortholog: 6q13 Cellular Component: cytosol Molecular Function:DNA binding; GTP binding; metal ion binding; ATP binding Biological Process: cyclic nucleotide biosynthetic process; positive regulation of interferon type I production; innate immune response; positive regulation of defense response to virus by host; defense response to virus; activation of innate immune response |
UniProt Code: | Q8N884 |
NCBI GenInfo Identifier: | 115511030 |
NCBI Gene ID: | 115004 |
NCBI Accession: | NP_612450.2 |
UniProt Secondary Accession: | Q8N884,Q14CV6, Q32NC9, Q5SWL0, Q5SWL1, Q96E45, L0L2J9 |
UniProt Related Accession: | Q8N884 |
Molecular Weight: | 58.3 kDa |
NCBI Full Name: | cyclic GMP-AMP synthase |
NCBI Synonym Full Names: | Mab-21 domain containing 1 |
NCBI Official Symbol: | MB21D1 |
NCBI Official Synonym Symbols: | cGAS; h-cGAS; C6orf150 |
NCBI Protein Information: | cyclic GMP-AMP synthase; cGAMP synthase; protein MB21D1; mab-21 domain-containing protein 1 |
UniProt Protein Name: | Cyclic GMP-AMP synthase |
UniProt Synonym Protein Names: | Mab-21 domain-containing protein 1 |
UniProt Gene Name: | MB21D1 |
UniProt Entry Name: | CGAS_HUMAN |
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