| UniProt Protein Function: | Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Cytoskeletal Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cortical actin cytoskeleton; cytoplasm; extracellular space; focal adhesion; intercellular junction; membrane; nuclear matrix; nucleus; vesicle Molecular Function:actin binding; protein binding Biological Process: actin cytoskeleton organization and biogenesis; actin filament depolymerization; axon guidance; blood coagulation; cytokinesis after mitosis; cytoskeleton organization and biogenesis; ephrin receptor signaling pathway; establishment of cell polarity; innate immune response; negative regulation of apoptosis; neural crest cell migration; neural fold formation; platelet activation; platelet degranulation; positive regulation of actin filament depolymerization; protein amino acid phosphorylation; regulation of cell morphogenesis; response to amino acid stimulus; response to virus; Rho protein signal transduction |
| NCBI Summary: | The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004] |
| UniProt Code: | P23528 |
| NCBI GenInfo Identifier: | 116848 |
| NCBI Gene ID: | 1072 |
| NCBI Accession: | P23528.3 |
| UniProt Secondary Accession: | P23528,Q53Y87, Q9UCA2, B3KUQ1, |
| UniProt Related Accession: | P23528 |
| Molecular Weight: | 18,502 Da |
| NCBI Full Name: | Cofilin-1 |
| NCBI Synonym Full Names: | cofilin 1 |
| NCBI Official Symbol: | CFL1 |
| NCBI Official Synonym Symbols: | CFL; cofilin; HEL-S-15 |
| NCBI Protein Information: | cofilin-1 |
| UniProt Protein Name: | Cofilin-1 |
| UniProt Synonym Protein Names: | 18 kDa phosphoprotein; p18; Cofilin, non-muscle isoform |
| Protein Family: | Cofilin |
| UniProt Gene Name: | CFL1 |
| UniProt Entry Name: | COF1_HUMAN |
