Anti-CES1 Antibody (CAB11478)
- SKU:
- CAB11478
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CES1 Antibody |
| 抗体コード: | CAB11478 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human CES1 |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | HepG2, Mouse liver, Mouse kidney, Rat lung, Rat liver, Rat kidney |
| 免疫原: | A synthesized peptide derived from human CES1 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 1066 |
| Uniprot: | P23141 |
| セルラーロケーション: | Endoplasmic reticulum lumen |
| 計算された分子量: | 55kDa |
| 観察された分子量: | 63KDa |
 | Western blot - CES1 Rabbit mAb (CAB11478) |
| 同義語: | ACAT, CE-1, CEH, CES2, HMSE, HMSE1, PCE-1, REH, SES1, TGH, hCE-1 |
| バックグラウンド: | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| UniProt Protein Function: | CES1: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Hydrolase; Xenobiotic Metabolism - drug metabolism - other enzymes; EC 3.1.1.56; EC 3.1.1.1 Chromosomal Location of Human Ortholog: 16q22.2 Cellular Component: extracellular space; endoplasmic reticulum lumen Molecular Function:methylumbelliferyl-acetate deacetylase activity Biological Process: epithelial cell differentiation; metabolic process; response to toxin |
| NCBI Summary: | This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. Mutations of this gene cause carboxylesterase 1 deficiency. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P23141 |
| NCBI GenInfo Identifier: | 119576 |
| NCBI Gene ID: | 1066 |
| NCBI Accession: | P23141.2 |
| UniProt Related Accession: | P23141 |
| Molecular Weight: | Predicted Molecular Mass: 34.0kDaAccurate Molecular Mass: 35kDa as determined by SDS-PAGE reducing conditions. |
| NCBI Full Name: | Liver carboxylesterase 1 |
| NCBI Synonym Full Names: | carboxylesterase 1 |
| NCBI Official Symbol: | CES1 |
| NCBI Official Synonym Symbols: | CEH; REH; TGH; ACAT; CE-1; CES2; HMSE; SES1; HMSE1; PCE-1; hCE-1 |
| NCBI Protein Information: | liver carboxylesterase 1 |
| UniProt Protein Name: | Liver carboxylesterase 1 |
| UniProt Synonym Protein Names: | Acyl-coenzyme A:cholesterol acyltransferase; ACAT; Brain carboxylesterase hBr1; Carboxylesterase 1 (EC:3.1.1.1); CE-1; hCE-1; Cocaine carboxylesterase; Egasyn; HMSE; Methylumbelliferyl-acetate deacetylase 1 (EC:3.1.1.56); Monocyte/macrophage serine esterase; Retinyl ester hydrolase; REH; Serine esterase 1; Triacylglycerol hydrolase; TGH |
| Protein Family: | Liver carboxylesterase |
| UniProt Gene Name: | CES1 |
| UniProt Entry Name: | EST1_HUMAN |