Anti-CERKL Antibody (CAB15984)
- SKU:
- CAB15984
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CERKL Antibody |
| 抗体コード: | CAB15984 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 359-558 of human CERKL (NP_001025482.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: | Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 359-558 of human CERKL (NP_001025482.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LAEK YRWM SPNQ RRDF AVVK ALAK LKAE DCEI SFLP FNSS DDVQ ERRA QGSP KSDC NDQW QMIQ GQFL NVSI MAIP CLCS VAPR GLAP NTRL NNGS MALI IARN TSRP EFIK HLKR YASV KNQF NFPF VETY TVEE VKVH PRNN TGGY NPEE EEDE TASE NCFP WNVD GDLM EVAS EVHI RLHP RLIS LYGG SMEE MIPK |
| 遺伝子ID: | 375298 |
| Uniprot: | Q49MI3 |
| セルラーロケーション: | Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Nucleus, nucleolus, nucleolus, trans-Golgi network |
| 計算された分子量: | 19kDa, 24kDa, 42-62kDa |
| 観察された分子量: | 63kDa |
| 同義語: | CERKL, RP26 |
| バックグラウンド: | This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts. |
| UniProt Protein Function: | CERKL: Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. Defects in CERKL are the cause of retinitis pigmentosa type 26 (RP26). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP26 inheritance is autosomal recessive. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleolus; Kinase, other Chromosomal Location of Human Ortholog: 2q31.3 Disease: Retinitis Pigmentosa 26 |
| NCBI Summary: | This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.[provided by RefSeq, May 2010] |
| UniProt Code: | Q49MI3 |
| NCBI GenInfo Identifier: | 84028814 |
| NCBI Gene ID: | 375298 |
| NCBI Accession: | Q49MI3.1 |
| UniProt Secondary Accession: | Q49MI3,Q49MH9, Q49MI0, Q49MI1, Q49MI2, Q5DVJ2, Q5DVJ4 Q5DVJ5, Q6UZF6, Q6ZP59, B2RPL2, B4DEY1, |
| UniProt Related Accession: | Q49MI3 |
| Molecular Weight: | 57,632 Da |
| NCBI Full Name: | Ceramide kinase-like protein |
| NCBI Synonym Full Names: | ceramide kinase like |
| NCBI Official Symbol: | CERKL |
| NCBI Official Synonym Symbols: | RP26 |
| NCBI Protein Information: | ceramide kinase-like protein |
| UniProt Protein Name: | Ceramide kinase-like protein |
| Protein Family: | Ceramide kinase-like protein |
| UniProt Gene Name: | CERKL |
| UniProt Entry Name: | CERKL_HUMAN |
 | Western blot analysis of extracts of mouse kidney, using CERKL antibody (CAB15984) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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