Anti-CEP164 Antibody (CAB9964)
- SKU:
- CAB9964
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-CEP164 Antibody |
| 抗体コード: | CAB9964 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 730-829 of human CEP164 (NP_055771.4). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | A375 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 730-829 of human CEP164 (NP_055771.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EASE KSEQ AALN AAKE KALQ QLRE QLEG ERKE AVAT LEKE HSAE LERL CSSL EAKH REVV SSLQ KKIQ EAQQ KEEA QLQK CLGQ VEHR VHQK SYHV AGYE |
| 遺伝子ID: | 22897 |
| Uniprot: | Q9UPV0 |
| セルラーロケーション: | Cytoplasm, Nucleus, centriole, centrosome, cytoskeleton, microtubule organizing center |
| 計算された分子量: | 163kDa/164kDa |
| 観察された分子量: | 164kDa |
| 同義語: | CEP164, NPHP15 |
| バックグラウンド: | This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CEP164: Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. Defects in CEP164 can be a cause of nephronophthisis-related ciliopathies (NPHP-RC), a group of recessive diseases that affect kidney, retina and brain. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 11q23.3 Cellular Component: centriole; centrosome; cytosol; extracellular space; nucleoplasm Molecular Function:protein binding Biological Process: cilium biogenesis; G2/M transition of mitotic cell cycle Disease: Nephronophthisis 15 |
| NCBI Summary: | This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012] |
| UniProt Code: | Q9UPV0 |
| NCBI GenInfo Identifier: | 162416241 |
| NCBI Gene ID: | 22897 |
| NCBI Accession: | Q9UPV0.3 |
| UniProt Secondary Accession: | Q9UPV0,Q6PKH9, Q7Z2X9, Q9NVS0, Q9UFJ6, |
| UniProt Related Accession: | Q9UPV0 |
| Molecular Weight: | 163,544 Da |
| NCBI Full Name: | Centrosomal protein of 164 kDa |
| NCBI Synonym Full Names: | centrosomal protein 164 |
| NCBI Official Symbol: | CEP164 |
| NCBI Official Synonym Symbols: | NPHP15 |
| NCBI Protein Information: | centrosomal protein of 164 kDa |
| UniProt Protein Name: | Centrosomal protein of 164 kDa |
| Protein Family: | Centrosomal protein |
| UniProt Gene Name: | CEP164 |
| UniProt Entry Name: | CE164_HUMAN |
 | Western blot analysis of extracts of A-375 cells, using CEP164 Antibody (CAB9964) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using CEP164 antibody (CAB9964) (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat liver using CEP164 antibody (CAB9964) (40x lens). |
 | Immunohistochemistry of paraffin-embedded rat heart using CEP164 antibody (CAB9964) (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver damage using CEP164 antibody (CAB9964) (40x lens). |
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