Anti-CEP135 Antibody (CAB15364)
- SKU:
- CAB15364
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CEP135 Antibody |
| 抗体コード: | CAB15364 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 841-1140 of human CEP135 (NP_079285.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 841-1140 of human CEP135 (NP_079285.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LEAA VQEK EEMK SRVH KYIT EVSR WESL MAAK EKEN QDLL DRFQ MLHN RAED WEVK AHQA EGES SSVR LELL SIDT ERRH LRER VELL EKEI QEHI NAHH AYES QISS MAKA MSRL EEEL RHQE DEKA TVLN DLSS LREL CIKL DSGK DIMT QQLN SKNL EFER VVVE LENV KSES DLLK KQLS NERH TVKN LESL LATN RDKE FHSH LTSH EKDT EIQL LKEK LTLS ESKL TSQS RENT MLRA KVAQ LQTD YDAL KRQI STER YERE RAIQ EMRR HGLA TPPL SSTL RSPS HSPE HRNV |
| 遺伝子ID: | 9662 |
| Uniprot: | Q66GS9 |
| セルラーロケーション: | Cytoplasm, centriole, centrosome, cytoskeleton, microtubule organizing center |
| 計算された分子量: | 28kDa/133kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | CEP135, CEP4, KIAA0635, MCPH8 |
| バックグラウンド: | This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8. |
| UniProt Protein Function: | CEP135: Centrosomal protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Defects in CEP135 are the cause of microcephaly, primary, type 8 (MCPH8). MCPH8 is a disease defined as a head circumference more than 3 standard deviations below the age- related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. Belongs to the CEP135/TSGA10 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 4q12 Cellular Component: centriole; centrosome; cytosol Molecular Function:protein binding; protein C-terminus binding Biological Process: centriole replication; centriole-centriole cohesion; G2/M transition of mitotic cell cycle; mitotic cell cycle; organelle organization and biogenesis Disease: Microcephaly 8, Primary, Autosomal Recessive |
| NCBI Summary: | This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8. [provided by RefSeq, Jun 2012] |
| UniProt Code: | Q66GS9 |
| NCBI GenInfo Identifier: | 296434460 |
| NCBI Gene ID: | 9662 |
| NCBI Accession: | Q66GS9.2 |
| UniProt Secondary Accession: | Q66GS9,O75130, Q58F25, Q9H8H7, B2RMY0, |
| UniProt Related Accession: | Q66GS9 |
| Molecular Weight: | 28,910 Da |
| NCBI Full Name: | Centrosomal protein of 135 kDa |
| NCBI Synonym Full Names: | centrosomal protein 135 |
| NCBI Official Symbol: | CEP135 |
| NCBI Official Synonym Symbols: | CEP4; MCPH8; KIAA0635 |
| NCBI Protein Information: | centrosomal protein of 135 kDa |
| UniProt Protein Name: | Centrosomal protein of 135 kDa |
| UniProt Synonym Protein Names: | Centrosomal protein 4 |
| Protein Family: | Centrosomal protein |
| UniProt Gene Name: | CEP135 |
| UniProt Entry Name: | CP135_HUMAN |
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