| UniProt Protein Function: | Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. |
| NCBI Summary: | The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q96BT3 |
| NCBI GenInfo Identifier: | 126722969 |
| NCBI Gene ID: | 80152 |
| NCBI Accession: | NP_079358.3 |
| UniProt Secondary Accession: | Q96BT3,Q96I29, Q96IC6, Q96NK9, Q9H901, |
| UniProt Related Accession: | Q96BT3 |
| Molecular Weight: | Observed: 65 kDaPredicted: 61 kDa |
| NCBI Full Name: | centromere protein T |
| NCBI Synonym Full Names: | centromere protein T |
| NCBI Official Symbol: | CENPT |
| NCBI Official Synonym Symbols: | CENP-T; C16orf56 |
| NCBI Protein Information: | centromere protein T |
| UniProt Protein Name: | Centromere protein T |
| UniProt Synonym Protein Names: | Interphase centromere complex protein 22 |
| Protein Family: | Centromere protein |
| UniProt Gene Name: | CENPT |
